摘要
目的：观察精制吴茱萸胶囊对于偏头痛小鼠的治疗作用。方法：给小鼠皮下注射利血平（１０ｍｇ／ｋｇ）１４ｄ，并脑室注射鼠凝血块（２μｌ／只），灌胃给药３ｄ，测痛阈值（热板法），并取血及脑测５ＨＴ、５ＨＩＡＡ、Ｈｉｓｔａｍｉｎｅ等。结果：精制吴茱萸胶囊能延长凝血时间，调节５ＨＴ的过度降低，提高痛阈，抑制脑内炎性刺激物的升高。
Aim:Study of the effect of refined Wuzhuyu capsule on the migraine′s mice.Methods:Injectiong of reserpine(10mg/kg,ih) to the mice for 14 days first,and injection of the mouse′s blood clotting (2ul/mouse) to the ventricular at day 14.And then giving the capsule (ig) for 3 days.Testing the pain threshold (hot plate),and 5 HT,5 HIAA,histamine of the brain and the blood.Results:The capsule can treat the pathologic mice effectively:prolonging the clotting time,regulating the concentration of 5 HT,increasing the pain threshold,decreasing the inflammatory stimulating materials in the brain.Conclusion:The capsule can treat the migraine′s mice by lower 5 HT and the spasm of local cerebral blood vessels.
出处
《中药药理与临床》
CAS
CSCD
1998年第5期4-6,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家科委95攻关课题
