摘要
目的：比较生脉注射液（ＩＳＭ）与西地兰（ＤＳＮＳ）对阿霉素（ＡＤＲ）引起心脏损伤的保护作用。方法：以ＡＤＲ处理Ｗｉｓｔａｒ大鼠造成心脏损伤模型，同时ｉｐＩＳＭ、ＤＳＮＳ，到期测血中ＳＧＯＴ、ＬＤＨ及同功酶、ＨＢＤＨ、ＳＯＤ、ＭＤＡ并进行心肌病理检查。结果：ＩＳＭ、ＤＳＮＳ组与ＡＤＲ组相比，血中ＳＯＤ升高，ＭＤＡ降低。ＩＳＭ组ＳＧＯＴ、ＬＤＨ、ＨＢＤＨ及ＬＤＨ１／ＬＤＨ２比值降低，心肌病理计分下降。ＤＳＮＳ组除ＬＤＨ１／ＬＤＨ２比值降低外，血中ＳＧＯＴ、ＬＤＨ、ＨＢＤＨ无显著性差异，心肌病理检查提示轻度保护作用，但无统计学意义。
Objective:To observe the protective effect of injection of Shengmai (SM) and Deslanosidum (Des) on cardioc toxicity of adriamycin (ADR) in rat. Methods:The protective effect was studied in the model of Wistar rat used adriamycin and ADR was ip with or without ISM or Des qd for 9d.The activity of serum glutamic oxalacetic transaminase (GOT),lactic dehydrogenase (LDH) and isoenzyme,α hydroxybutyrate dehydrogenase (HBDH),superoxide dismutase (SOD) and the concentration of malodialdehyde (MDA) were assayed.At the same time,the rat's mycardial pathomorphism was deteted. Results:As compared with the ADR group,the activity of serum SOD was increased and that of serun MDA,LDH,HBDH and the ratio of LDH 1/LDH 2 were decreased in ISM group,but in Des group only was the tatio of LDH 1/LDH 2 decreased.They also inhibit the extent of mycardial pathological damege,but it has no significance in Des group. Conclusion:The protective effect of Shengmai on the adriamycin cardiotoxicity in rats is stronger than that of deslanosidum.
出处
《中药药理与临床》
CAS
CSCD
1998年第1期5-7,共3页
Pharmacology and Clinics of Chinese Materia Medica
