摘要
目的 :研究补阳还五汤在治疗慢性原发性肾小球肾炎中对ET、CGRP的作用。方法 :45例患者分为 2组 ,常规治疗组 19例 (用雷公藤多甙片、潘生丁片、保肾康片治疗 ) ;常规 +补阳还五汤组 2 6例 (在常规治疗基础上加补阳还五汤口服 )。观察治疗前后血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)水平。结果 :慢性肾炎患者血浆ET水平高于正常人 (P <0 .0 1)而CGRP水平低于正常人 (P <0 .0 1) ,经治疗以后均显著改善 (P <0 .0 1) ,且以常规 +补阳还五汤组改善更为显著 ,与常规组治疗后比较 ,P <0 .0 1。结论 :补阳还五汤能改善慢性肾炎患者ET。
To study the mechanism of Buyang Huanwu Decoction (BHD) in treating chronic primary glomerulonephritis (CPP) diseases. Methods: patients with CPP diseases were divided into two groups: (1) usual medicine treatment group (treated with multi glycosides of Tripterygium wilfordii, persatin, Baoshenxkang et al); (2) usual medicine and BHD treatment group (treated with usual medicine and BHD et al). The plasma endothelin (ET) and calcitonin gene related peptide (CGRP) levels were observed before and after treatment. Results: The levels of ET of CPP in patients was higher than that in normal group before treatment (P<0.01), and the levels of CGRP was lower (P<0.01). The changes of ET, CGRP before and after treatment were signifficant (P<0.01), the improvment of ET, CGRP in usual and BHD treatment group was better than that in usual medicine treatment group (P<0.01). Conclusion: BHD had the ability of improving the unblance of ET,CGRP in patients with CPP diseases.
出处
《中药药理与临床》
CAS
CSCD
2000年第3期36-37,共2页
Pharmacology and Clinics of Chinese Materia Medica
关键词
补阳还五汤
慢性肾炎
内皮素
降钙素基因相关钛
药理学
Buyang Huanwu Decoction
chronic primary glomerulonephritis
endothelin
calcitonin gene related peptide<
