期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

慢性心房颤动对人心房肌细胞内游离钙浓度的影响 被引量：1

Study of The Influence of Chronic Atrial Fibrillation on Intracellualr Calcium Concentration of Atrial Myocytes of Human.
下载PDF
导出
摘要 用激光共聚焦显微镜技术 ,以Fluo 3作为钙指示剂 ,对急性分离的风湿性心脏病 (RHD)慢性心房颤动 (AF)和RHD窦性心律患者的心房肌细胞内游离Ca2 + 浓度进行比较、测定。观察RHD慢性AF患者心房肌细胞内是否存在钙超载。结果 :RHD慢性AF患者心房肌细胞内游离Ca2 + 浓度明显高于窦性心律患者心房肌细胞内游离Ca2 +浓度 (5 17± 98vs 2 6 2± 6 5nmol/L ,P <0 .0 1)。研究提示RHD慢性AF可以引起患者心房肌细胞内Ca2 + To find out whether atrial fibrillation(AF) leads to intracellular calcium overload in atrial myocytes,intracellular free calcium concentration in acute isolated atrial myocytes of rheumantic heart disease(RHD) patients with AF and with sinus rhythm was measured with laser scanning cofocal microscopy technique using the fluoresent Ca 2+ indicator Fluo 3.Result:Intracellular free calcium concentration of patients with AF was significantly higher than that of patients with sinus rhythm(517±98 vs 262±65 nmol/L, P <0.01).Conclution:Chronic AF could lead to intracellular calcium overload in atrial myocytes of human.
作者 周更须 梁延春 张荣庆 王春梅 蔡振杰 贾国良
机构地区 第四军医大学西京医院心血管外科中心 第四军医大学西京医院心脏内科 第四军医大学中心实验室
出处 《中国心脏起搏与心电生理杂志》 2002年第1期34-36,共3页 Chinese Journal of Cardiac Pacing and Electrophysiology
关键词 慢性心房颤动 心房重构 钙超载 Fluo-3 Atrial fibrillation,chronic Atrial remodeling Calcium overload Fluo 3
分类号 R541.75 [医药卫生—心血管疾病] R331.38 [医药卫生—人体生理学]
  • 相关文献

参考文献14

  • 1[1]Wijffels MMEF,Kirchhof CJHJ,Dorland R,et al.Atrial fibrillation begets atrial fibrillation:a study in awake chronicaly instrumented goats[J].Circulation,1995,92:1954
  • 2[2]Tieleman RG,De Langen CDJ,Van Gelder IC,et al.Verapamil reduces tachycardia-induced electrical remodeling of the atria[J].Circulation,1997,95:1945
  • 3[3]Tieleman RG,Vangelder IC,Crijns HAGM,et al.Early recurrences of atrial fibrillation after electrical cardioversion:A result of fibrillation induced electrical remodeling of the atria[J]?J Am Coll Cardiol,1998,31:167
  • 4[4]Ausma J,Wijffels M,Thone F,et al.Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat[J].Circulation,1997,96:3157
  • 5[5]Fareh S,Thibault B,Nattel S,et al.Treatment with a T-type calcium channel blocker prevents atrial fibrillation caused by tachycardia induced atrial remodeling(abstract)[J].Circulation,1998,98:Ⅰ-210
  • 6[6]Zygmunt AC,Maylie J.Stimulation dependent faciliation of the high threshold calcium current in guinea-pig ventricular myocytes[J].J Physiol(Lond),1990,428:653
  • 7[7]Piot C,Lemaire S,Albat B,et al.High frequency induced upregulation of human cardiac calcium currents[J].Circulation,1996,93:120
  • 8[8]Tohse N,Kameyama M,Irisawa H,et al.Intracelluar Ca2+ and protein kinase C modulate K+ current in guinea ipig heart cells[J].Am J Physiol,1987,253:H1321
  • 9[9]Zygmunt AC,Gibbons WR.Properties of the calcium-activated chloride current in heart[J].J Gen Physiol,1992,99:391
  • 10[10]Morgan JP.Abnormol intracellular modulation of calcium as a major cause of cardiac contractile dysfunction[J].N Engl Med,1991,325:625

同被引文献15

  • 1[1]Van - Wagoner DR,Nerbonne JM.Molecular basis of electrical remodeling in atrial fibrillation[J] .J Mol Cell Cardiol,2000,Jun,32:1101.
  • 2[2]Brundel BJJM,Van Gelder IC,Henning RH,etal.Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial fibrillation [ J ].Cardiovas Res,1999,42: 443.
  • 3[4]Yamada J,OhkusaT,Nao T,et al.Up-regulation of inositol 1,4,5-trisphosphate receptor expression in atrial tissue in patients with chronic atrial fibrillation[J].JACC,2001,37: 1111.
  • 4[5]Lai LP,SuMJ,Lin JL,etal .Down- regulation of L- type calcium channel and sarcoplasmic reticular Ca2 + - ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor,calsequestrin and phospholamban[ J ] .JACC,1999,33:1230.
  • 5[6]OhkusaT,Ueyama T,Yamada,etal.Alterations in cardiac sarcoplasmic reticulum Ca2 + regulatory proteins in the atrial tissue of patients with chronic atrial fibrillation[J] .J Am Coll Cardiol ,1999,34:255.
  • 6[7]Cao KJ,Xia XJ,Shan QJ,etal.Changes of sarcoplasmic reticular Ca2 + - ATPase and 1P3 - I receptor mRNA expression in patients with atrial fibrillation[J] .Chin Med J,2002,115(5) :664.
  • 7[8]Van Wagoner DR,Pond AL,McCarthy PM,etal.Outward K + current densities and Kv I.5 expression are reduced in chronic human atrial fibrillation[J].Circ Res,1997,80: 772.
  • 8[9]Yue L,Melnyk P,Gaspo R,et al .Molecular mechanism underlying ionic remodeling in a dog model of atrial fibrillation[J ].Cir Res,1999,84: 776.
  • 9[10]Li GR,Nattel S.Properties of human atrial Ica at physiological temperatures and revelance to action potential[J].Am J Physiol,1997,272:H227.
  • 10[11]Yue L,Feng J,Gaspo R,et al.Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation[J].Circ Res,1997,81:512.

引证文献1

二级引证文献4

中国心脏起搏与心电生理杂志
2002年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部