摘要
目的探索六味地黄丸联合鲑鱼降钙素对改善绝经后骨质疏松性疼痛症状的疗效。方法 136例绝经后骨质疏松症患者随机分为治疗组(68例)和对照组(68例)。对照组给予鲑鱼降钙素治疗,治疗组给予六味地黄丸联合鲑鱼降钙素治疗,为期治疗3个月。检测治疗后两组患者数字疼痛评分(NRS)、视觉模拟疼痛评分(VAS)、Oswestry功能障碍指数(ODI)和JOA下腰功能评分(JOA)改变,血清胰岛素样生长因子-1 (IGF-1),肿瘤坏死因子-α(TNF-α)、I型胶原C端肽(CTX-I)和抗酒石酸酸性磷酸酶-5b(TRACP-5b)的水平改变;同时记录治疗有效率和药物不良反应。结果治疗前,两组的骨代谢指标、炎症因子水平和NRS、VAS、ODI和JOA评分比较差异无统计学意义(P>0.05)。治疗3个月后,两组NRS、VAS、ODI和JOA评分都有不同程度的改善,其中治疗组上述评分改善更明显,和对照组比较差异有明显的统计学意义(P<0.05);治疗后各组血清TRACP-5b、TNF-α和CTX-I水平较治疗前均降低(P<0.05),IGF-1水平较治疗前明显升高(P<0.05),而治疗组改变更明显,两组比较差异有明显的统计学意义(P<0.05)。治疗组治疗有效率显著高于对照组,而药物不良反应比较差异无统计学意义(P>0.05)。结论六味地黄丸联合鲑鱼降钙素对改善绝经后骨质疏松性疼痛症状效果显著。
Objective To explore the efficacy of six-ingredient rehmannia pill combined with salmon calcitonin on the pain symptom in postmenopausal osteoporosis. Methods A total of 136 patients with postmenopausal osteoporosis were randomly divided into treatment group (N=68) and control group (N=68). The patients in the control group received salmon calcitonin, and the patients in the treatment group received six-ingredient rehmannia pill combined with salmon calcitonin for 3 months. The levels of tumor necrosis factor-α (TNF-α), type I collagen C-terminal peptide (CTX-I), tartrate-resistant acid phosphatase-5b (TRACP-5b), insulin-like growth factor-1 (IGF-1), and the scores of NRS, VAS, Oswestry dysfunction index (ODI), and JOA (JOA) in the two groups were determined. At the same time the efficacy and adverse drug reaction were record. Results Before the treatment, there were no statistically significant differences in bone metabolic parameters, inflammatory factors, and scores of NRS, VAS, ODI, and JOA between the two groups (P>0.05). After 3 months of treatment, the scores of NRS, VAS, ODI, and JOA in the two groups improved to varying degrees. The above-mentioned scores in the treatment group improved more significantly, and there was a statistically significant difference compared with the control group (P<0.05). After treatment, the levels of serum TRACP-5b, TNF-α, and CTX-I were lower than before treatment (P<0.05), and IGF-1 levels were significantly higher than before treatment (P<0.05). The change was more significant in the treatment group. There was a statistically significant difference between the two groups (P<0.05). The efficacy in the treatment group was significantly higher than that in the control group. The adverse drug reaction was not statistically significant (P>0.05). Conclusion Six-ingredient rehmannia pill combined with salmon calcitonin has significant effect on relieving postmenopausal osteoporotic pain symptom.
作者
王玺
罗志秀
WANG Xi;LUO Zhixiu(The Fourth Wuhan Hospital,Wuhan 430034,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2018年第11期1485-1488,共4页
Chinese Journal of Osteoporosis
关键词
绝经后骨质疏松症
疼痛
六味地黄丸
鲑鱼降钙素
骨代谢
postmenopausal osteoporosis
pain
six-ingredient rehmannia pill
salmon calcitonin
bone metabolism
