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气道上皮趋化因子与肺部炎症反应的研究进展 被引量:34

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摘要 气道上皮细胞是呼吸系统与外界接触的第一道屏障细胞。越来越多的研究表明气道上皮细胞在气道局部炎症的形成过程中发挥着核心作用。趋化因子是引起炎性细胞迁移的最直接最迅速的效应因子,迄今为止研究发现气道上皮细胞表达的趋化因子主要有2个家族:CC家族和CXC家族。CC家族趋化因子主要有CCL2、CCL5、CCL11、CCL17和CCL20等,CXC家族趋化因子主要有CXCL1、CXCL5、CXCL8和CXCL10等。此外,气道上皮细胞还表达TSLP和IL-33等未归类于4个家族的其他趋化因子。病原刺激后,气道上皮细胞通过表达不同的趋化因子特异性趋化中性粒细胞、嗜酸性粒细胞、单核细胞、树突状细胞、T淋巴细胞和先天淋巴样细胞等炎症细胞,引起气道局部的炎性浸润,参与哮喘和慢性阻塞性肺疾病等肺部炎症疾病的发生、发展。
出处 《广东医学》 CAS 2018年第21期3277-3282,共6页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81270065 81370116 81570026) 湖南省自然科学基金和国家重点基础研究发展计划项目(973项目)(编号:2015JJ2147)
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