摘要
[目的]研究新疆维吾尔族人群ABCG2基因多态性和高尿酸血症易感性的关系。[方法]采用病例-对照研究的方法,收集维吾尔族高尿酸血症组1 024例,对照组1 033例,采用Sequenom Mass ARRAY?SNP技术检测新疆维吾尔族对象中ABCG2基因多态性位点rs117104615、rs1448784、rs2231137、rs2231142、rs2622621、rs2622626基因型,并进行基因模型分析,筛检出疾病易感性的单核苷酸多态性(SNPs)。[结果]在高尿酸血症组和对照组间对ABCG2基因6个位点的基因型和等位基因进行比较,发现rs2231142位点CA和AA基因型具有较高的高尿酸血症发病风险,其OR及95%CI分别为1.586(1.305~1.929)、1.807(1.171~2.788);A等位基因具有较高的高尿酸血症发病风险,OR及95%CI分别为1.505(1.284~1.763)。rs2622626位点G等位基因是高尿酸血症发病的保护因素,具有较低的高尿酸血症发病风险(OR=0.861,95%CI:0.759~0.977)。经年龄、性别、吸烟等协变量调整后rs2231142在显性模型中CC是高尿酸血症的保护因素(P <0.05),OR(95%CI)为0.562(0.468~0.676);rs2622626的隐性模型中GT、TT基因型增加高尿酸血症的风险,OR(95%CI)为1.312(1.026~1.676)。[结论] ABCG2的rs2622626和rs2231142位点单核苷酸多态可能与维吾尔族高尿酸血症发病的易感性有关联。
[Objective ]To study the association between ABCG2gene polymorphisms and hyperuricemia susceptibility in Xinjiang Uygur population. [Methods ]A case-control study was conducted in 1024Uygur hyperuricemia patients and 1033 healthy controls.Sequenom Mass ARRAY■SNP technique was used to detect the polymorphisms of ABCG2 gene in the subjects,including rs117104615, rs1448784,rs2231137,rs2231142,rs2622621,and rs2622626.Single nucleotide polymorphisms (SNPs)associated with the susceptibility to the disease were identified by genetic model analysis. [Results ]When comparing the genotypes and alleles of six loci ofABCG2 gene between the hyperuricemia group and the control group,the risk of hyperuricemia was higher in the subjects carrying CA (OR=1.586,95%CI:1.305-1.929)and AA (OR=1.807,95%CI: 1.171-2.788)genotypes of rs2231142locus;the risk was also higher in those carrying A allele (OR=1.505,95%CI:1.284-1.763).The G allele at rs2622626locus was a protective factor for hyperuricemia,and was associated with a lower risk of hyperuricemia (OR=0,861, 95%CI:0.759-0.977).In the dominant model of rs2231142adjusted for selected covariances (age,sex,smoking,etc.),CC was a protective factor in the Uygur population (OR=0.562,95%CI:0.468-0.676,P<0.05).In the recessive model of rs2622626,GT and TT genotypes increased the risk of hyperuricemia (OR=1.312,95%CI:1.026-1.676). [Conclusion ]SNPs at rs2622626and rs2231142loci of ABCG2 gene may be associated with susceptibility to hyperuricemia in Uygurs.
作者
王婷婷
朱佳
雍娴婷
陈婷
苏银霞
王志强
姚华
WANG Ting-ting;ZHU Jia;YONG Xian-ting;CHEN Ting;SU Yin-xia;WANG Zhi-qiang;YAO Hua(College of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;People's Hospital of Xinjiang Uygur Autonomous Region of the Cadre Health Care Center,Urumqi,Xinjiang 832002,China;Metabolic Disease Lab,The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China.)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2018年第11期1002-1006,1011,共6页
Journal of Environmental and Occupational Medicine
基金
国家自然科学基金项目(编号:81660140)
新疆维吾尔自治区自然科学基金项目(编号:2017D001C183)
新疆医科大学大学生创新计划(编号:CX2017149)
