摘要
目的:探讨帕唑帕尼药品不良反应的发生规律及特点,为安全合理用药提供参考。方法:以"帕唑帕尼"和"不良反应"以及"pazopanib"和"adverse reactions"为检索词,检索2009年10月—2017年8月CNKI,VI,Wanfang及PubMed数据库收载的帕唑帕尼药品不良反应个案报道,并进行分析。结果:共筛选出有效个案报道26篇,共计33例患者,男性16例,女性17例,年龄50岁及以上患者20例(60. 6%)。使用帕唑帕尼后3月内出现不良反应26例(78. 8%)。33例不良反应患者,死亡7例。结论:帕唑帕尼药品不良反应需引起临床高度重视,要加强用药监测,以减少致命性不良反应的发生。
Objective :To analyze the general patterns and characteristics of adverse drug reactions induced by pazopanib and provide reference for clinical medication.Methods:The case reports of adverse drug reactions induced by pazopanib were collected and analyzed statistically from CNKI,VIP,Wanfang and PubMed from October 2009to August 2017,using "pazopanib"and "adverse reactions"as the keywords.Results:A total of 26 reports involving 33patients were screened out,including 16men and 17women.Patients over the age of 50years showed higher incidence (n =20,60.6%).Seven patients died of adverse reactions induced by pazopanib.Conclusion: Adverse drug reactions induced by pazopanib should be paid attention to and closely monitored for early detection to reduce the incidences of fatal adverse drug reactions.
作者
程军
汪龙
CHENG Jun;WANG Long(Department of Pharmaceutical,the Third People's Hospital of Bengbu,Bengbu 233000,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2018年第22期2717-2720,共4页
Chinese Journal of New Drugs
关键词
帕唑帕尼
药品不良反应
文献分析
pazopanib
adverse drug reactions
literature analysis
