摘要
凝血酶敏感蛋白-1(TSP-1)作为一种重要的抑制血管生成物质,在人体组织中广泛分布,并且在不同组织部位肿瘤的形成、生长、分化、转移中占据不可代替的地位。TSP-1在各类肿瘤(如膀胱癌、乳腺癌、前列腺癌、非小细胞肺癌、胰腺癌等)的发生、发展中起着重要的作用,近年研究证实凝血酶敏感蛋白-1对口腔颌面部恶性肿瘤血管生成及肿瘤发生、发展的抑制作用也尤为明显。本文对TSP-1在全身肿瘤及口腔颌面部恶性肿瘤中的研究进展进行综述。
Thrombospondin-1(TSP-1)is widely distributed in human tissues and is important in inhibiting angiogenesis. It also occupies an indispensable position in the formation,growth,differentiation,and metastasis of tumors in different tissues. TSP-1 plays an important role in the occurrence and development of various types of tumors.The inhibitory effect of TSP-1 on the angiogenesis and tumor development of oral and maxillofacial malignant tumors has been demonstrated in recent years. This paper reviews the findings and progress of TSP-1 research involving all kinds of tumors as well as oral and maxillofacial malignancies.
作者
周雪琴
任俊
杨森
Zhou Xueqin;Ren Jun;Yang Sen(Graduate School,Zunyi Medical University,Zunyi 563000,China;Dept.of Oral and Maxillofacial Surgery,Suining Central Hospital,Suining 629000,China.)
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2018年第6期686-690,共5页
West China Journal of Stomatology
基金
中华口腔医学会西部行口腔医学临床科研基金(CSA-W-2016-01)
四川省科技支撑计划项目(2014SZ0038)
四川省医学科研青年创新课题(Q14054)
四川省科技计划重点研发项目(20-18FZ0113)~~
