摘要
聚(酯酰胺)(PEA)的主链中同时具有酯键和酰胺键,兼具了聚酯(polyester)的生物降解性和相容性以及聚酰胺(polyamide)优异的机械性能,在药物控释、组织工程以及热塑性弹性体等领域应用广泛。缩合聚合是合成聚酯酰胺最初的方法,近年来开环聚合(ROP)成为制备聚酯酰胺的主要策略,本文从环状单体均聚、环状单体共聚、环状单体和线形单体共聚等方面总结了聚酯酰胺合成的研究进展。同时,介绍了基于多组分聚合反应(MCP)的新合成方法,并对聚酯酰胺材料的发展进行了探讨和展望。
Poly (ester amide)(PEA)is a class of functional polymers with both amide and ester linkages in the polymer main chains.Due to the outstanding biodegradability,biocompatibility and mechanical property,PEA has broad applications in drug delivery,tissue engineering and thermoplastic elastomer.Polycondensation is the original synthetic method to PEA.Recently,remarkable achievements have been made in synthesis of PEA via ring-opening polymerization(ROP).This review summarizes the progress in ROP of cyclic monomers,ringopening copolymerization (ROCP)of cyclic monomers and ROCP of cyclic/linear momomers.Moreover, multicomponent polymerization (MCP)is highlighted as a novel synthetic strategy to prepare PEA.The challenge and outlook of PEA are also discussed.
作者
高晗
徐军
胡欣
朱宁
郭凯
Han Gao;Jun Xu;Xin Hu;Ning Zhu;Kai Guo(College of Biotechnology and Pharmaceutical Engineering,State Key Laboratory of Material Chemistry Engineering,Nanjing Tech University,Nanjing 211800,China;College of Materials Science and Engineering,Nanjing Tech University,Nanjing 211800,China;Caprolactam Division,SINOPEC Baling Company,Yueyang 414000,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2018年第11期1634-1645,共12页
Progress in Chemistry
基金
国家自然科学基金项目(No.21878145
21504039
21522604
U1463201)
江苏省先进生物制造创新中心(No.XTD1823
XTD1821
XTB1802)资助~~
关键词
聚酯酰胺
开环聚合
多组分聚合
poly (ester amide)
ring-opening polymerization
multicomponent polymerization
