摘要
目的探讨强化无错性节奏治疗对稳定期精神分裂症患者认知功能的影响。方法对符合DSM-Ⅳ精神分裂症诊断标准的90例稳定期患者,采用随机数字表法分为对照组(n=45)和试验组(n=45);研究周期12周,期间抗精神病药种类和治疗剂量不变。对照组为自然状态下观察,试验组采用强化无错性节奏治疗。分别于基线及治疗12周末采用MATRICS认知评估系统(MCCB)评定患者认知功能。结果基线时2组间MCCB总分及分量表分比较差异均无统计学意义(P>0.05)。治疗12周末,2组MCCB总分改善值[(5.7±5.2)分与(1.9±8.2)分,t=2.34,P=0.02]、加工速度改善值[(2.7±6.2)分与(-3.7±10.5)分,t=3.19,P=0.02]、工作记忆改善值[5.0±9.2)分与(0.3±8.6)分,t=2.34,P=0.02]、言语记忆改善值[(6.5±7.2)分与(-0.4±9.2)分,t=3.70,P<0.01]、推理与问题解决改善值[(3.7±10.1)分与(-1.9±10.1)分,t=2.45,P=0.02]比较差异有统计学意义。结论强化无错性节奏治疗可有效改善稳定期精神分裂症患者的认知功能,尤其对加工速度、言语记忆、工作记忆以及推理解决能力改善显著。
Objective To explore the effects of music therapy (Intensiveerror-free rhythm training) on cognitive function in stable schizophrenic patients.Methods Ninety stable patients who were diagnosed as schizophrenia by the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) were enrolled and randomly divided into treatment group (n=45) and control group(n=45).In the following 12 weeks,the patients in treatment group were trained with an intensive error-free rhythm music program,and the ones in the control group were observed in a standard routine program without music training.The antipsychotics were not specially changed in terms of the types or dosage in both grouPs.MATRICS Consensus Cognitive Battery (MCCB) was employed to assess the effect of the cognitive function at the baseline and at the endpoint.Repeated measures analysis of variance was used to analyze differences between the two groups.Results There are no statistics differences at the baseline between the groups on the MCCB total score and the subscale scores (P>0.05).At the end of 12 weeks' treatment,the improvement of MCCB total score ((5.7±5.2) vs.(1.9± 8.2),t=2.34,P=0.02),processing speed ((2.7 ± 6.2) vs.(-3.7-± 10.5),t=3.19,P=0.02),working memory ((5.0 ± 9.2) vs.(0.3±8.6),t=2.34,P=0.02),verbal learning and memory ((6.5±7.2) vs.(-0.4±9.2),t=3.70,P<0.01),as well as reasoning and problem solving ((3.7 ± 10.1) vs.(-1.9 ± 10.1),t=2.45,P=0.02) showed significant differences.Conclusion Rhythm music training may be a good way to be explored for improving the cognitive functioning of the schizophrenic patients in their rehabilitation process.
作者
冯薇
贾强
谭淑平
于婷
李佳
王志仁
尹誉霏
杨甫德
田莉
谭云龙
Feng Wei;Jia Qiang;Tan Shuping;Yu Ting;Li Jia;Wang Zhiren;Yin Yufei;Yang Fude;Tian Li;Tan Yunlong(Belting Huilongguan Hospital,Peking University Huilongguan Clinical Medical School,Beijing 100096,China)
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2018年第6期363-366,共4页
Chinese Journal of Psychiatry
基金
北京市医管局临床技术创新项目(XMLX201513)
国家自然科学基金国际(地区)合作项目(中芬)(81461130016).
关键词
音乐治疗
精神分裂症
节奏训练
认知功能
Music therapy
Schizophrenia
Rhythm training
Cognitive function
