摘要
目的:探讨活血通窍方治疗阿尔茨海默病的临床疗效。方法:将120例阿尔茨海默病患者随机分为治疗组与对照组,每组60例。对照组采用安理申治疗,治疗组予活血通窍方治疗。比较两组治疗2个月、4个月、6个月中医证候疗效、智能疗效、生活能力疗效以及血同型半胱氨酸、维生素B12、叶酸水平。结果:治疗2个月、4个月、6个月后,治疗组中医证候疗效均优于对照组,差异均有统计学意义(P<0.05);治疗2个月、4个月、6个月后,治疗组智力水平与生活能力改善总有效率均明显高于对照组,差异均有统计学意义(P<0.05);治疗后,治疗组维生素B12与叶酸水平均明显低于对照组,同型半胱氨酸水平明显高于对照组,差异均有统计学意义(P<0.05);治疗组与对照组用药安全性相近,差异无统计学意义(P>0.05)。结论:活血通窍方可明显减轻阿尔茨海默病患者临床症状,获得良好的智能疗效与生活能力疗效,有利于提高患者生活质量,延缓机体衰退速度。
Objective:To investigate the clinical effect of Huoxue Tongqiao formulaon alzheimer disease (AD).Methods:A total of 120AD patients were divided into treatment and control groups by random number table,60cases in each.Patients were treated by donepezil in control group and Huoxue Tongqiao formula in treatment group.The TCM syndrome efficacy,brainpower efficacy,efficacy of living ability,homocysteine,vitamin Bz2and folic acid levels were compared between the two groups after treatment for two,four and six months. Results:After treatment for two,four and six months,the treatment group showed better TCM syndrome efficacy than control group,and the difference was statistical (P<0.05);After treatment for two,four and six months,the treatment group showed higher intelligence level and effective rate of living ability improvement than the control group,with statistical difference (P<0.05);After treatment,the treatment group showed lower level of the vitamin Bj2and folic acid than control group,while higher level of homocysteine than control group (P<0.05);The safety of medication was similar between the two groups,and there was no statistical difference (P>0.05).Conclusion: Huoxue Tongqiao formula can significantly reduce clinical symptoms in AD patients,achieve good efficacy of brainpower and living ability,increase quality of living,and delay body's recession and prolong survival period.
作者
金翔
张微
张德新
刘智宇
马彪
梅群丽
陈茂华
JIN Xiang;ZHANG Wei;ZHANG De-xin;LIU Zhi-yu;MA Biao;MEI Qun-li;CHEN Mao-hua(Yichang Hospital of Traditional Chinese Medicine,Yichang Hubei 443000,China)
出处
《中医药导报》
2018年第20期93-96,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
三峡大学青年科学基金项目(KJ2016A026)
关键词
阿尔茨海默病
活血通窍方
智能
生活能力
中医证候
alzheimer disease
Huoxue Tongqiao formula
brainpower
living ability
TCM syndrome
