摘要
青光眼是全球首位不可逆性致盲眼病,原发性闭角型青光眼(PACG)则是青光眼的常见类型之一.研究表明PACG的发病与多种因素相关,其中包括眼解剖因素和遗传易感性.与PACG发病相关的解剖结构,如前房深度、晶状体的相对位置及厚度、房角状态、眼轴长度等均具有遗传倾向,而遗传度正是量化遗传倾向的指标,因此遗传度研究为解释疾病的遗传易感性以及理解疾病的发病机制提供了重要线索.本文针对与PACG有关的解剖结构遗传度研究进行综述,以期为临床研究提供参考.(中华眼科杂志.20i8.54:864-867)。
Glaucoma is the leading cause of irreversible blindness throughout the world.Primary angle closure glaucoma (PACG)is one of the common types of this disease.Research indicates that its prevalence is always associated with many factors,including ocular anatomical characteristics and the genetic susceptibility.According to many studies,phenotypes related to PACG,such as anterior chamber depth, relative lens position and thickness,chamber angle state,and axial length,are heritable.Heritability is an important indicator to quantify this genetic tendency.Therefore,the study of heritability plays an important role in explaining the genetic susceptibility and understanding the mechanism of these diseases.This article reviews the heritability of the phenotypes that relate to PACG.(Chin J Ophthalmol,2018,54:864-867).
作者
杨晓晗
乔春艳
Yang Xiaohan;Qiao Chunyan(Belting Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology &Visual Sciences Key Lab.,Beijing 100730,China)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2018年第11期864-867,共4页
Chinese Journal of Ophthalmology
基金
国家自然科学基金(81570837).
关键词
青光眼
闭角型
前房
晶体
轴长度
眼
疾病遗传易感性
Glaucoma,angle-closure
Anterior chamber
Lens,crystalline
Axial length, eye
Genetic predisposition to disease
