摘要
建立香草中的MAM-2201、AM-2201、5F-AKB48、AKB48和JWH-210五种合成大麻素GC-MS/MS-SRM确证检测方法。将已知含有MAM-2201、AM-2201、5F-AKB48、AKB48和JWH-210五种合成大麻素的香草样品,用甲醇超声提取后,进行GC-MS一级全扫描,然后采用优化的GC-MS/MS"定时SRM"模式进行测定。结果显示,经GC-MS/MS检验,香草基质的5种合成大麻素得到很好的分离,同时还对5种合成大麻素可能的质谱碎裂途径进行分析,并建立了这5种合成大麻素二级质谱图库。该方法检验具有快速、准确等优点,可以应用于香草中5种新型合成大麻素成分的鉴定。
A method was established for determination of AKB48,5F-AKB48,AM-2201,JW -210and MAM-220 1in novel "spice" drugs by GC-MS/MS.At first,the sample was dissolved in methanol,and was treated ultrasonically.The parent ions of each synthetic cannabinoid were detected by running GC/MS in a full scan mode,and then were analyzed by GC-MS/MS with "timed SRM"mode.The analysis results showed that 5 synthetic cannabinoids were well separated.And the fragmentation routes of 5 synthetic cannabinoids were proposed.The CID voltage for each parent ion was optimized and determined.The GC-MS/MS spectrum was characteristic.The qualitative analysis method is rapid and accurate,and is applicable to quantitative determination of MAM-2201,AM-2201,5F-AKB48,AKB48and JWH-210in novel "spice"drugs.
作者
朱晓红
彭海燕
徐雪松
林宏亮
ZHU Xiao-hong;PENG Hai-yan;XV Xue-song;LIN Hong-liang(Institute of Criminal Science and Technology,Wenzhou Public Security Bureau,Zhejiang Wenzhou 325000,China;Centre for Criminal Science and Teclmology,Rui'an Public Security Bureau,Zhejiang Rui'an 325200,China)
出处
《辽宁化工》
CAS
2018年第11期1184-1187,共4页
Liaoning Chemical Industry
