摘要
目的研究调强放射治疗(Intensity-modulated radiation therapy,IMRT)联合不同时期腔内放疗治疗子宫内膜癌疗效及对直肠膀胱并发症的影响。方法随机选取郑州大学第一附属医院放疗科2012年1月至2013年12月75例子宫内膜癌术后患者,随机分为腔内组(38例)和内外组(37例)。两组均采用IMRT联合腔内放疗,其中两组联合腔内放疗时期不同。腔内组于IMRT第一周末开始实施腔内放疗,内外组于第二周结束后进行。IMRT:1. 8 Gy,1次/d,5次/w,共45 Gy。腔内放疗每周一次,5 Gy/次,共6次。观察两组患者3、5年生存率及直肠膀胱不良反应的发生率。结果腔内组3年生存率(81. 6%)较内外组(67. 6%)比较,差异具有统计学意义P <0. 05;腔内组5年生存率(73. 3%)较内外组(76. 7%)比较,P> 0. 05;腔内组放射性直肠炎3、5年发生率分别为30. 0%和31. 8%,明显高于内外组6. 7%和4. 3%,差异具有统计学意义(P <0. 05);腔内组放射性膀胱炎3、5年发生率分别为16. 7%和13. 6%,与内外组相比3. 3%、4. 3%,P> 0. 05。结论外照射期间,两周后开始进行腔内放疗,在不影响远期疗效的同时可以明显减少放射性直肠炎发生。
Objective To study the efficacy of Intensity -modulated radiation therapy (IMRT)combined with intracavitary radiotherapy for endometrial cancer and its effect on recta and bladder complications.Methods Choose 75postoperative endometrial carcinoma patients,from the radiotherapy department of the First Affiliated Hospital of Zhengzhou University from January 2012to December 2013,divided them into intracavitary group (38cases)and pelvic with intracavitary group(37cases)randomly.Both groups used IMRT combined with intracavitary radiotherapy,in which the two groups had different periods of combined intracavitary radiotherapy.The intraeavitary group started intracavitary radiotherapy after one week's IMRT.The pelvic with intracavitary group started intracavitary radiotherapy after two week's IMRT.IMRT:1.8Gy,1 time/d,5times/w,45Gy in total.Intraeavitaryl radiotherapy once a week,5Gy/times,6times totally. Observe the two groups three -year and five -year survival rates and the incidence of rectal and bladder adverse reactions.Results The 3-year survival rate (81.6%)in the intracavitary group was significantly higher than the other group (67.6%).The difference was statistically significant (P <0.05).Compared the 5-year survival rate of intracavitary group (73.3%) with the other group (76.7%),P >0.05;The incidence of radiation proctitis in the intracavitary group was 30%and 31.8%,significantly higher than the other group 6.7%and 4.3%..The incidence.of radiation cystitis in the intracavitary group was 16.7%and 13.6%,compared with the other group 3.3%,4.3%,P >0.05. Conclusion During the period of IMRT,add intracavitary radiotherapy after two weeks IMRT.It can significantly reduce the incidence of radiation proctitis without affecting the long -term efficacy.
作者
宋娣
任永霞
刘梦圆
梁天嵩
杨道科
张月
SONG Di;REN Yong -xia;LIU Meng -yuan;LIANG Tian -song;YANG Dao -ke;ZHANG Yue(Department of Radiotherapy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《医药论坛杂志》
2018年第10期57-60,共4页
Journal of Medical Forum
