摘要
[目的]观察右归丸联合西药治疗老年高血压(肾阳亏虚)疗效。[方法]使用随机平行对照方法,将150例门诊住院按就诊顺序号抽签方法随机分为两组。对照组75例氢氯噻嗪,50mg/次,1次/d;美托洛尔,150mg/次,1～2次/d,据血压单独或联合使用,调整剂量。治疗组75例右归丸(地黄熟40g,山药20g,山茱萸、枸杞子、肉桂各15g,菟丝子、鹿角胶、杜仲各20g,附子制10g),失眠多梦加酸枣仁、远志、麦冬各15g;头痛中加川芎15g,细辛8g;小便清长加茯苓、泽泻各15g;腰膝酸软加牛膝、五加皮各15g,水煎300mL,1剂/d,早晚分服;西药治疗同对照组。连续治疗7d为1疗程。观测临床表现、舒张压、收缩压、中医证候积分、不良反应。连续治疗4疗程(28d),判定疗效。[结果]治疗组显效40例,有效30例,无效5例,总有效率93.33%;对照组显效36例,有效24例,无效15例,总有效率80.00%;治疗组疗效优于对照组(P<0.05)。舒张压、收缩压、中医证候积分两组均有降低(P<0.01),治疗组降低多于对照组(P<0.01)。[结论]右归丸联合西药治疗老年高血压(肾阳亏虚),可提高降压效果,改善伴随症状,值得推广。
[Objective]To observe the curative effect of Youguiwan combined with western medicine on senile hypertension (kidney yang deficiency).[Methods] 150 out-patient inpatients were randomly divided into two groups according to the order of visiting.75 cases in the control group were treated with hydrochlorothiazide 50 mg/time,once a day,metoprolol 150 mg/time,once to twice a day,and the dosage was adjusted according to the blood pressure.In the treatment group,75 cases were treated with Youguiwan (Shudihuang 40g,Shanyan 20g,Shanzhuyu,Gouqizi,Rougui each 15g,Tusizi,Lujiaojiao,Duzhong each 20g,Zhifuzi10g),insomnia,add Suanzaoren,Yuanzhi,Maidong each 15g;headache,add Chuanxiong 15g,Xixin 5g;frequency of urine,add Fulng,Zexie each 15g;soreness and weakness of waist and knees,add Niuxi,Wujiapi each 15g,decocted 300 mL,1 doses of/d,sooner or later divided;western medicine treatment with the control group.Continuous treatment of 7d for 1courses.Clinical manifestations,diastolic blood pressure,systolic blood pressure,TCM syndrome scores,and adverse reactions were observed.Continuous treatment of 4 courses (28d),determine the curative effect.[Results]The total effective rate was 93.33%in the treatment group of 40cases,30cases effective,5 cases ineffective;36 cases in the control group,24 cases effective,15 cases ineffective,the total effective rate was 80.00%;the curative effect of the treatment group was better than that of the control group (P<0.05).Diastolic blood pressure,systolic blood pressure and TCM syndrome score were decreased in both groups (P<0.01),and the decrease in treatment group was more than that in control group (P<0.01). [Conclusion]Yougui pill combined with western medicine in the treatment of senile hypertension (deficiency of kidney yang)can improve the antihypertensive effect,improve the accompanying symptoms,and is worth promoting.
作者
王美莺
WANG Meiying(Department of Traditional Chinese medicine,Amllated Hospital of Putian College,Putian 351100,Fujian,China)
出处
《实用中医内科杂志》
2018年第10期32-34,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
高血压
眩晕
肾阳亏虚
右归丸
氢氯噻嗪
美托洛尔
舒张压
收缩压
中医证候积分
中药复方
随机平行对照研究
hypertension
vertigo
kidney Yang deficiency(肾阳亏虚)
Youguiwan(右归丸)
hydrochlorothiazide
metoprolol
diastolic blood pressure
systolic blood pressure
TCM syndrome score
Chinese medicine compound
randomized parallel control study
