摘要
目的:系统评价中成药头痛宁胶囊治疗偏头痛的有效性、安全性。方法:检索2002年1月～2017年12月中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中国重要会议论文数据库(CPCD)、Cochrane library、Medline、Pub Med、OVID、MD CONSULT、Embase。收集有关头痛宁胶囊治疗偏头痛的随机对照试验(RCT),采用Cochrane系统评价的方法对纳入的文献进行质量评价,并使用Rev Man5.3.5软件进行Meta分析得出结论。结果:最后纳入了16篇RCT进入研究,包括患者2228例。并进行了Meta分析得出,中成药头痛宁胶囊治疗偏头痛与对照组比较,其有效率[OR=3.29,95%CI(2.56,4.24),P <0.00001]、不良反应发生率[(OR=0.55,95%CI(0.31,0.96),P=0.04)]差异有统计学意义。结论:现有证据表明,与对照组相比,中成药头痛宁胶囊治疗偏头痛疗效显著,且不良反应发生率较低。本文系统评价纳入的方法学质量较低,尚需要更多高质量的研究以增加证据的强度。
Objective:To estimate the effect and security of Toutongning(头痛宁) for Migraine.Methods:Date bases including CNKI,CBM,CDMD,CPCD,the Cochrane library,Medline,Pub Med,OVID,MD CONSULT and Embase from January 2002 to December 2017 were searched to collect randomized controlled trials(RCTs) data of Toutongning on Migraine treatment.Cochrane systematic assessment was used to evaluate the methodological quality,and meta-analysis was performed using software Rev Man 5.3.5.Results :A total of 16 RCTs involving 2228 patients were analyzed in the research.The results of meta-analysis showed a significant difference in effective rate [OR=3.37,95% CI(2.63,4.33),P<0.00001]and incidence of adverse reactions [(OR=0.55,95% CI(0.31,0.96),P=0.04) ]between two groups.Conclusion:Comparing with control groups,the current evidence shows the effectiveness is increased and the incidence of adverse reactions is decreased.Due to the limited quality of included studies,more high quality studies are needed to verify the above conclusion.
作者
吉萌萌
荆志伟
赵永烈
张村
Ji Mengmeng;Jing Zhiwei;Zhao Yonglie;Zhang Cun(China Academy of Chinese Medical Sciences,Beijing 100700;The Third Hospital,Beijing University of Chinese Medicine,Beijing 100029;Institute of Chinese Materia Mediea,China Academy of Chinese Medical Scienees,Beijing 100700)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2018年第5期121-124,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然科学基金项目(批准号:81473514)
中国中医科学院基本科研业务费自主选题项目(编号:ZZ11-042)
