摘要
斑蝥为较常用中药,因易引起毒性反应,临床常用其炮制品。斑蝥的中毒量和治疗量相近,安全范围窄,常用量小,稍有不慎即可导致中毒反应,主要由斑蝥素引起。本文通过查阅历史文献中对斑蝥毒的记载,结合现代研究分析斑蝥引起毒性反应的物质基础、分子机制、毒性反应的临床主要表现及对策,评价其毒性反应与药效活性的关系,以期为斑蝥毒的科学认识及其临床合理应用提供参考。
Mylabris,a common used traditional Chinese medicine,mostly used as processed products in clinic for its toxicity.The literature shows the toxic dose of mylabris is similar to the therapeutic dose,which is usually a low dose.The safety range is narrow,so poisoning reaction may be easily caused by eantharidin.In this paper,we reviewed historical literature of the mylabris toxicity and combined with the modem research to analyze the material basis,molecular mechanism,clinical manifestations and strategy.Also we evaluated the relationship between the toxic reaction and the pharmacodynamic effect,in order to provide further,scientific research on mylabris toxicity for more appropriate clinical application.
作者
方莲花
杜冠华
Fang Lianhua;Du Guanhua(Beijing Key Laboratory of Drug Target ReSearch and Drug Screening,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing 100050)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2018年第5期150-152,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家药典委员会项目(20170150号)；中国医学科学院医学与健康科技创新工程项目(No2017-12M-1-010)。
关键词
斑蝥
毒性反应
斑蝥素
药效活性
历史认识
mylabris
toxic reaction
cantharidin
pharmacodynamic activity
historical cognition
