摘要
目的:观察补肺活血化痰方配伍西药治疗慢性阻塞性肺疾病(COPD)并发肺动脉高压(PH)效果及对血气指标、血清基质金属蛋白酶~9 (MMP-9)、C反应蛋白(CRP)、降钙素原(PCT)和趋化因子配体18 (CCL-18)水平的影响。方法:选取86例COPD并发肺动脉高压患者并将就诊编号按分层随机法分为观察组(n=45)与对照组(n=41),对照组仅给予西药治疗,观察组则以补肺活血化痰方配伍西药治疗,对比两组临床疗效及肺功能指标、血气指标、血清MMP-9、CRP、PCT、CCL-18等指标水平。结果:疗程结束后,观察组肺功能指标、血气指标、血清MMP-9、CRP、PCT、CCL-18等指标水平的改善幅度、疗效等级均优于对照组,临床总有效率高达91. 11%,亦显著优于对照组的73. 17%,均P<0. 05。结论:较常规西药治疗,补肺活血化痰方配伍西药治疗COPD并发PH疗效更佳。
Objective:To analyze the effect of using Bufei Huoxue Huatan Recipe combined with western medicine in the treatment of chronic obstructive pulmonary disease (COPD)complicated with pulmonary hypertension (PH)and its-influence on blood gas index and serum matrix metalloproteinase-9(MMP-9),C reactive protein (CRP)and procalcitonin (PCT)and chemokine ligand 18(CCL-18)levels.Methods:86cases of COPD patients with pulmonary hypertension were selected and were divided into observation group (n =45)and controlled group(n =41)according to the visiting numbers and the stratified,randomization.The controlled group was treated with western medicine only,and the observation group was given the Bufei Huoxue Huatan Recipe combined with western medicine.The clinical efficacy,and the levels of pulmonary function indexes,blood gas index,serum MMP-9,CRP,PCT and CCL-18 were compared between the two groups.Results:At the end of the course,the improvement degree of the levels of lung function indexes,blood gas index,serum MMP-9,CRP,PCT and CCL-18,and the efficacy grades in the observation group were better than those in the controlled group,and the total effective rate was better than that in the controlled group (91.11% vs 73.17%),and all P <0.05.Conclusions:Compared with conventional western medicine,Bufei Huoxue Huatan Recipe combined with western medicine can have better efficacy in the treatment of COPD complicated with PH.
作者
徐丹
XU Dan(Beijing,Wangfu Hospital of Integrated Traditional Chinese and Western Medicine ,Beifing100049,China)
出处
《四川中医》
2018年第11期79-82,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
补肺活血化痰方
COPD并发肺动脉高压
血气指标
血清指标
Bufei Huoxue Huatan Recipe
COPD complicated with pulmonary hypertension
Blood gas index
Serum indexes
