摘要
80%细菌感染与细菌生物膜(简称菌膜)形成有关,相比于游离菌,菌膜对抗生素的耐受性提高10～1000倍,是造成目前细菌耐药的主要原因。了解菌膜的相关特征和耐药机制,有助于更好地解决因菌膜导致的细菌感染及耐药性问题。本文从菌膜的结构着手,介绍了菌膜的结构、主要形成方式和菌膜的相关耐药机制,在此基础上归纳了近年来发现的具有抗菌膜活性及与抗生素有协同作用的化合物,并总结了新晋纳米递药系统及分子印迹聚合物等抗菌膜新策略。
Eighty percent of bacterial infections are related to the formation of bacterial biofilm.Compared with planktonic bacteria,bacterial biofilm is 10-1000times more resistant to antibiotics,which is the main cause of current bacterial drug resistance.A comprehensive understanding of the characteristics and resistance mechanisms of bacteria biofilm will help us treat the stubborn infections caused by the bacterial biofilm better and solve the problem of bacterial drug resistance.In this review,the composition and quorum sensing of bacterial biofilm,two major patterns of biofilm formation and drug resistance mechanisms were presented. Furthermore,representative compounds with anti-biofilm activity and compounds synergistic with antibiotics in anti-biofilm actions were introduced.Nano drug delivery strategies used for anti-biofilm in recent years as well as a novel drug-delivery systerri molecularly imprinted polymer was also introduced.
作者
陈小楠
申元娜
李彭宇
邹祎晴
胡海燕
CHEN Xiao-nan;SHEN Yuan-na;LI Peng-yu;ZOU Yi-qing;HU Hai-yan(School of Pharmaceutical Sciences,Sun Yat-Sen University,Guangzhou 510006,China)
出处
《药学学报》
CAS
CSCD
北大核心
2018年第12期2040-2049,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81473154)
中山大学青年教师重点培育项目(18ykzd08)
关键词
细菌生物膜
耐药性
胞外聚合物
佐剂
药物传递系统
分子印迹聚合物
biofilm
drug resistance
extracellular polymeric substance
adjuvant
drug delivery system
molecular imprinted polymer
