摘要
目的探讨妊娠高血压患者血清中内皮素-1(Endothelin-1,ET-1)、抵抗素(Resistin)、脑钠肽(brain natriuretic peptide,BNP)水平与患者病情及妊娠结局的关系。方法选取本院2015年11月-2016年11月诊断为妊娠高血压的78例患者作为研究对象,所有患者均检测血清中ET-1、Resistin、BNP水平,探讨其与妊娠高血压患者病情及妊娠结局的关系,并采用Logistic回归分析探讨ET-1、Resistin、BNP水平与患者妊娠结局的关系。结果重度妊娠组患者血清中ET-1、Resistin、BNP水平均明显高于中度妊娠组和轻度妊娠组,妊娠期糖尿病妊娠结局不良组ET-1、Resistin、BNP水平均明显高于妊娠结局良好组的患者,差异均有统计学意义(P <0. 05)。Logistic回归分析结果显示,BMI指数、ET-1、重度妊娠高血压、Resistin、BNP是妊娠高血压患者不良结局的独立危险因素(P <0. 05)。结论妊娠高血压患者血管内皮素、抵抗素、脑钠肽水平是妊娠结局预后不良的独立危险因素。
Objective To investigate the relationship between serum endothelin-1( ET-1),resistin,brain natriuretic peptide( BNP) and the pregnancy outcome in patients with pregnancy induced hypertension. Methods Seventy-eight patients with pregnancy induced hypertension were selected from our hospital from September 2013 to September 2016,who were conducted for the detection of serum ET-1,Resistin and BNP levels,and their relationships with the hypertension disease and pregnancy outcome were explored. Logistic regression analysis was adopted to explore the relationship between ET-1,Resistin and BNP levels and pregnancy outcome. Results Serum ET-1,Resistin and BNP levels in patients with severe pregnancy were significantly higher than that of moderate pregnancy group and mild pregnancy group; the serum ET-1,Resistin,BNP levels in gestational diabetes mellitus group with adverse pregnancy outcomes were significantly higher than that of pregnancy group with good outcome,with the differences statistically significant( P < 0. 05). Logistic regression analysis showed that BMI,ET-1,severe pregnancy hypertension,Resistin and BNP were independent risk factors for adverse outcomes in patients with pregnancy-induced hypertension( P < 0. 05). Conclusion Vascular endothelial growth factor,Resistin and brain natriuretic peptide were independent risk factors in patients with pregnancy induced hypertension.
作者
牟丹
MOU Dan(Department of Obstetrics and Gynecology,Lichuan People's Hospital,Lichuan,Hubei 445400,China)
出处
《中国卫生检验杂志》
CAS
2018年第23期2876-2878,共3页
Chinese Journal of Health Laboratory Technology
关键词
妊娠高血压
血管内皮素
抵抗素
脑钠肽
Pregnancy induced hypertension
Endothelin
Resistin
Brain natriuretic peptide
