摘要
[目的]研究探讨胰管内支架置入在慢性胰腺炎治疗中的临床价值。[方法]选择2015年1月～2017年5月;我院就诊的90例慢性胰腺炎患者;分组方法:数字随机表法。90例患者被随机分为对照组(45例)与观察组(45例),对照组实施保守治疗,观察组在保守治疗基础上实施胰管内支架置入治疗,比较2组的临床疗效、症状缓解时间、住院时间、血清炎症因子指标、免疫功能指标、不良反应发生情况、复发情况。[结果](1)在临床疗效方面,观察组的总有效率高于对照组(P<0.05)。(2)在症状缓解时间及住院时间方面,观察组的腹部不适、发热、血淀粉酶异常增高等症状缓解时间均短于对照组(P<0.05),其住院时间也短于对照组(P<0.05)。(3)在血清炎症因子指标方面,治疗后,2组的CRP、IL-6、PCT均较治疗前降低(P<0.05),而观察组的CRP、IL-6、PCT均低于对照组(P<0.05)。(4)在免疫功能指标方面,治疗后,2组CD3+、CD4/CD8等免疫功能指标均较治疗前增高(P<0.05),而观察组的各项免疫功能指标高于对照组(P<0.05)。(5)在不良反应发生情况方面,观察组与对照组的总发生率比较,差异无统计学意义(P>0.05)。(6)在复发情况方面,治疗后随访1年观察发现,观察组的复发率低于对照组(P<0.05)。[结论]胰管内支架置入应用于慢性胰腺炎治疗中,可提高其临床疗效,促使症状缓解,还可抑制患者机体内炎症反应,改善其免疫功能,减少复发,且不良反应较少,安全性可靠。
[Objective]To study the clinical value of pancreatic stent implantation in the treatment of chronic pancreatitis.[Methods]From January 2015 to May 2017,90 patients with chronic pancreatitis in our hospital were studied.90 patients were randomly divided into control group(45 cases)and observation group(45 cases).The control group was treated with conservative therapy,the observation group was treated with pancreatic stents on the basis of conservative treatment,and the clinical effects of the two groups were compared.Symptom remission time,hospitalization time,serum inflammatory factor index,immune function index,adverse reaction occurrence and recurrence.[Results](1)in terms of clinical efficacy,the total effective rate of the observation group was higher than that of the control group(P<0.05).(2)in remission time and length of hospital stay,the observation group of abdominal discomfort,fever,the symptom such as abnormal blood amylase increased ease time is shorter than the control group(P<0.05),the length of hospital stay is shorter than the control group(P<0.05).(3)in terms of serum inflammatory factors,CRP,IL-6 and PCT of the two groups were lower after treatment than before treatment(P <0.05),while CRP,IL-6 and PCT of the observation group were lower than those of the control group(P<0.05).(4)on the immune function indicators,after treatment,two groups of CD3 +,CD4/CD8 immune function index are higher than before treatment(P<0.05),and immune function indicators of observation group is higher than the control group(P<0.05).(5)in terms of adverse reactions,there was no statisti-cally significant difference in the overall incidence between the observation group and the control group(P>0.05).(6)in terms of recurrence,the one-year follow-up observation after treatment found that the recurrence rate of the observation group was lower than that of the control group(P<0.05).[Conclusion]The application of intrapancreatic stents in the treatment of chronic pancreatitis can improve the clinical efficacy,promote the relief of symptoms,inhibit the inflammatory reaction,improve the immune function,reduce the recurrence,and have fewer adverse reactions.
作者
苏嘉文
刘玉华
许哲
黎婉媚
SU Jia-wen;LIU Yu-hua;XU Zhe;LI Wan-mei(Department of Gastroenterology,Dongguan People's Hospital,Guangdong,Dongguan 523000,China)
出处
《中国中西医结合消化杂志》
CAS
2018年第11期951-954,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
慢性胰腺炎
介入治疗
胰管内支架置入
Chronic pancreatitis
Interventional therapy
Intrapancreatic stent placement
