摘要
目的分析给予多索茶碱与氨茶碱治疗支气管哮喘急性发作老年患者的疗效及对肺功能的影响。方法选择某院2015年9月～2018年3月诊治的86例老年支气管哮喘急性发作患者为研究对象,随机分为研究组与对照组,每组43例。对照组使用氨茶碱治疗,研究组予以多索茶碱治疗,比较两组治疗效果。结果治疗后,研究组总有效率为97.67%(42/43),比对照组[81.40%(35/43)]高;研究组喘息缓解时间、咳嗽缓解时间、湿啰音消除时间、哮鸣音消失时间等均明显短于对照组,差异均有统计学意义(P<0.05);治疗后,研究组FVC、FEV1、FEV1/FVC等均明显高于对照组,且差异均有统计学意义(P<0.05);研究组不良反应发生率(6.98%)明显低于对照组(23.26%),差异有统计学意义(P<0.05)。结论与氨茶碱比较,多索茶碱对老年患者支气管哮喘急性发作的效果更佳,可有效缩短临床症状缓解时间,改善肺功能,且不良反应少,安全可靠,值得推广应用。
OBJECTIVE To analyze the effects of doxofylline and aminophylline on lung function in elderly patients with acute attack of bronchial asthma. METHODS A total of 86 cases of elderly patients with acute bronchial asthma who were diagnosed and treated in a hospital from September 2015 to March 2018 were selected as study subjects,and randomly divided into study group and control group,with 43 cases in each group. The control group was treated with aminophylline,while the study group was treated with doxofylline,and the results were compared between the two groups. RESULTS After treatment,the total effectiveness of the study group was 97.67%( 42/43) higher than that of the control group[81.40%( 35/43) ].In the study group,wheezing relief time,cough relief time,humidity erasure time and wheezing disappearance time were significantly shorter than those in the control group,with statistically significant differences( P<0.05).After treatment,FVC,FEV1 and FEV1/FVC in the study group were significantly higher than those in the control group,and all had statistical significance( P < 0. 05). The incidence of adverse reactions in the study group( 6.98%) was significantly lower than that in the control group( 23. 26%),with statistically significant differences( P < 0. 05).CONCLUSION Compared with aminophylline,doxofylline has a better effect on the acute attack of bronchial asthma in elderly patients,can effectively shorten the time of remission of clinical symptoms,improve lung function,and have fewer adverse reactions,which is safe,reliable and worthy of popularization and application.
作者
黄宇浩
HUANG Yuhao(Xingning People's Hospital ,Xingning,Guangdong514500,China)
出处
《今日药学》
CAS
2018年第11期759-761,共3页
Pharmacy Today
关键词
氨茶碱
多索茶碱
支气管哮喘
疗效
肺功能
症状
aminophylline
doxofylline
bronchial asthma
curative effect
lung function
symptoms
