摘要
睡眠障碍在阿尔茨海默病(AD)患者中普遍存在,是最早出现的临床症状。研究发现睡眠障碍促使β淀粉样蛋白(Aβ)在大脑中积累,形成有毒性作用的淀粉样斑块,抑制突触传递通路,诱发tau蛋白异常磷酸化,最终导致神经突触功能障碍。此外,Aβ引发的炎症反应和应激反应也可诱发AD。因此,改善睡眠障碍成为治疗AD的新方向,尤以光疗法效果最为显著。本文就睡眠障碍影响AD的发病机制及治疗相关最新研究进展综述如下。
Sleep disorders commonly exist and are the earliest clinical symptoms in Alzheimer's disease (AD).At present,the molecular mechanism of AD caused by sleep disorders is not clear.Recent studies have found that sleep disorders can promote the accumulation of beta amyloid (Aβ)in the brain to form amyloid plaques with toxic effects.The increased Aβ inhibits the synaptic transmission pathway and induces abnormal phosphorylation of tau protein,which eventually leads to synaptic dysfunction.In addition,the inflammatory and stress response induced by Aβ are also associated with AD.Therefore,the improvement of sleep disorders may be a new pathway for the treatment of AD,in which light therapy is proved to be particularly effective.This article reviewes the latest progresses in the influences of sleep disorders in pathogenesis and treatment of AD in recent years.
作者
石静
娄诗云
杨思敏
林倩
洪芬芳
杨树龙
Shi Jing;Lou Shiyun;Yang Simin;Lin Qian;Hong Fenfang;Yang Shulong(Department of Experimental Teaching Center,Nanchang University,Nanchang 330006,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2018年第12期1290-1295,共6页
Chinese Journal of Neuromedicine
关键词
阿尔茨海默病
睡眠障碍
光疗法
Alzheimer's disease
Sleep disorder
Light therapy
