摘要
目的 评价羟考酮联合连续胸椎旁神经阻滞(TPVB)用于微创冠状动脉旁路移植术后镇痛的效果.方法 择期全麻下行微创冠状动脉旁路移植术患者32例,年龄60~75岁,体重50~85 kg,ASA分级Ⅱ或Ⅲ级.采用随机数字表法分为2组(n=16):吗啡+TPVB组(MT组)和羟考酮+TPVB组(OT组).麻醉诱导前经T4,5间隙行左侧胸椎旁间隙穿刺并置管,注射0.375%罗哌卡因15 ml,然后持续输注0.375%罗哌卡因5 ml∕h维持至手术结束前0.5 h.术后行PCA,MT组使用吗啡1 mg∕ml,OT组使用羟考酮1 mg∕ml,总量60 ml,参数设置:负荷剂量2 mg,背景输注速率1 mg∕h,PCA剂量1 mg,锁定时间10 min,每4 h最大限量20 mg.静脉注射哌替啶50 mg进行补救镇痛,维持VAS评分≤4分.记录术中芬太尼用量、术后48 h内PCA镇痛药用量、PCA总按压次数∕有效按压次数比值、补救镇痛药物用量、补救镇痛情况、镇痛满意度评分、气管拔管时间、ICU滞留时间及术后住院时间.记录术后72 h内恶心呕吐、瘙痒、呼吸抑制、肺不张、嗜睡的发生情况.结果 与MT组比较,OT组术中芬太尼用量、PCA镇痛药用量、补救镇痛药物用量、补救镇痛率和PCA总按压次数∕有效按压次数比值降低,镇痛满意度评分升高,气管拔管时间及ICU滞留时间明显缩短,恶心呕吐、瘙痒、呼吸抑制、嗜睡的发生率降低(P<0.05).结论 羟考酮联合连续TPVB用于微创冠状动脉旁路移植术患者术后镇痛安全有效.
Objective To evaluate the efficacy of oxycodone combined with thoracic paravertebral block ( TPVB) for postoperative analgesia in patients undergoing minimally invasive direct coronary artery bypass grafting ( MIDCABG) . Methods Thirty-two American Society of Anesthesiologists physical statusⅡorⅢpatients of both sexes, aged 60-75 yr, weighing 50-85 kg, scheduled for elective MIDCABG un-der general anesthesia, were divided into 2 groups ( n=16 each) using a random number table method:morphine plus TPVB group ( group MT) and oxycodone plus TPVB group ( group OT) . Paravertebral cathe-ter was placed at T4,5 before induction of anesthesia to perform left thoracic paravertebral puncture, patients were tracheally intubated, and 0. 375% ropivacaine 15 ml was injected followed by continuous infusion of 0. 375% ropivacaine 5 ml∕h until 0. 5 h before the end of surgery. Both groups received patient-controlled analgesia ( PCA) after surgery. The PCA solution contained 1 mg∕ml morphine 60 ml in group MT or 1 mg∕ml oxycodone 60 ml in group OT, and the PCA pump was set up to deliver a 1 mg bolus dose with a 10-min lockout interval and background infusion at 1 ml∕h after a loading dose of 2 mg, with the maximum dose of 20 mg every 4 h. Pethidine 50 mg was intravenously injected as a rescue analgesic to maintain visual ana-log scale≤4. The intraoperative consumption of fentanyl, consumption of analgesics for PCA within 48 h after surgery, ratio of total to effective pressing times of PCA, consumption of analgesics for rescue analge-sia, requirement for rescue analgesia, score of satisfactory analgesia, extubation time, duration of inten-sive care unit stay and length of hospital stay were recorded. The development of nausea and vomiting, pru-ritus, respiratory depression, atelectasis and somnolence was recorded within 72 h after surgery. Results Compared with group MT, the intraoperative consumption of fentanyl, consumption of analgesics for PCA, consumption of analgesics for rescue analgesia, requirement for rescue analgesia and ratio of total to effec-tive pressing times of PCA were significantly decreased, the score of satisfactory analgesia was increased, the extubation time and duration of intensive care unit stay were shortened, and the incidence of nausea and vomiting, pruritus, respiratory depression and somnolence was decreased in group OT (P<0. 05). Con-clusion Oxycodone combined with TPVB provides safe and effective efficacy for postoperative analgesia in patients undergoing MIDCABG.
作者
李秋杰
王彬
孙立新
马福国
张彦平
王明山
Li Qiufie;Wang Bin;Sun Lixin;Ma Fuguo;Zhang Yanping;Wang Mingshan(Department of Anesthesiology,Qingdao Municipal Hospital,Qingdao 266071,China)
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2018年第8期942-945,共4页
Chinese Journal of Anesthesiology
基金
青岛市优秀青年医学人才项目(YQ2014Y15).
