摘要
目的:观察健脾益肾方联合常规胰岛素对妊娠期糖尿病患者血脂、血糖水平及妊娠结局的影响。方法:取2015年1月至2016年6月于本院就诊的妊娠期糖尿病患者96例为研究对象,随机分为观察组和对照组,每组各48例。对照组患者给予常规胰岛素治疗,观察组在对照组的基础上联合健脾益肾方治疗。比较两组患者治疗前后血糖指标[空腹血糖(fasting blood glucose,FBG)、餐后血糖(Postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)及夜间血糖]、血脂水平[三酰甘油(three acyl glycerin,TG)、血清总胆固醇(total cholesterol,TC)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)]及妊娠结局。结果:两组患者治疗后夜间血糖、FBG、2 h PBG及Hb A1C水平显著低于治疗前,且观察组低于对照组,差异具有统计学意义(P <0. 05)。两组患者治疗后TC、TG、LDL-C水平显著低于治疗前,HDL-C显著高于治疗前,观察组TC、TG、LDL-C显著低于对照组,HDL-C高于对照组,差异均有统计学意义(P <0. 05)。观察组剖宫产、妊娠期高血压、羊水过多、产后出血、感染发生率均显著低于对照组,差异具有统计学意义(P <0. 05。观察组新生儿早产、巨大儿、新生儿窒息、胎儿窘迫、胎儿畸形发生率显著低于对照组,差异具有统计学意义(P <0. 05)。结论:健脾益肾方联合常规胰岛素治疗妊娠期糖尿病,能够显著降低妊娠期糖尿病患者的血脂、血糖水平,改善妊娠结局。
Objective: To observe the influence of Spleen-Fortifying and Kidney-Nourishing Decoction combined with routine insulin therapy on blood lipid and blood glucose level and pregnancy outcome in patients with gestational diabetes mellitus. Methods: Ninety-six patients with gestational diabetes mellitus who were treated in our hospital from January 2015 to June 2016 were randomly divided into the observation group and the control group,with 48 cases in each group. Patients in the control group were given conventional insulin treatment,while the ones in the observation group were treated with Spleen-Fortifying and Kidney- Nourishing Decoction on the basis of the control group. Then the fasting blood glucose ( FBG) ,postprandial blood glucose ( PBG) ,glycosylated hemoglobin ( HbA1c) ,night fasting blood glucose ( FBG) ,the blood lipid levels [including three acyl glycerin ( TG) ,total cholesterol ( TC) ,low density lipoprotein cholesterol ( LDL-C0) and high density lipoprotein cholesterol ( HDL-C) ],and pregnancy outcome. Results: After the treatment,the levels of night blood glucose,FBG,2-hour PBG and HbA1C in the two groups were significantly lower than those before treatment,and the observation group was lower than the control group,and all the differences were statistically significant ( P < 0. 05) . After the treatment,the levels of TC,TG and LDLC in the two groups were significantly lower than those before the treatment,and the level of HDL-C in the observation group was significantly higher than that before the treatment ( P < 0. 05) ,and the levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group,and all the differences were statistically significant ( P < 0. 05) . The incidences of cesarean section,pregnancy-induced hypertension,excessive amniotic fluid,postpartum hemorrhage and infection in the observation group were significantly lower than those in the control group,and all the differences were statistically significant ( P < 0. 05) . The incidences of premature delivery,macrosomia,neonatal asphyxia,fetal distress and fetal malformation in the observation group were significantly lower than those in the control group,and all the differences were statistically significant ( P < 0. 05) . Conclusion: Spleen-Fortifying and Kidney-Nourishing Decoction combined with routine insulin therapy has a remarkable clinical effect on estational diabetes mellitus,can significantly reduce the blood lipids and blood sugar levels of patients, and improve their pregnancy outcomes.
作者
高璐
GAO Lu(The Third Hospital Attached to Henan University of CM,Zhengzhou,Henan,China,450008)
出处
《河南中医》
2018年第11期1728-1730,共3页
Henan Traditional Chinese Medicine
基金
河南省科技攻关计划项目(编号:971200100)
关键词
妊娠期糖尿病
健脾益肾方
胰岛素
妊娠结局
estational diabetes mellitus
insulin
Spleen-Fortifying and Kidney-Nourishing Decoction
pregnancy outcome
