摘要
目的检测急性冠状动脉综合征(ACS)患者B型利钠肽(BNP)、同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平,并分析其与心肌梗死溶栓(TIMI)危险评分的相关性。方法选取2017年1-12月中国医科大学附属盛京医院第三心血管内科接受治疗的ACS患者90例作为ACS组,根据TIMI危险评分将其分为高危亚组33例、中危亚组30例、低危亚组27例,另选取同期在医院接受治疗的稳定型心绞痛(SAP)患者40例作为SAP组,同期在医院体检显示冠状动脉造影正常的志愿者40例作为对照组。比较各组BNP、Hcy及hs-CRP水平,分析TIMI危险评分与ACS患者病变分支的关系,以及ACS患者BNP、Hcy及hs-CRP水平与TIMI危险评分的相关性。结果 ACS组的BNP、Hcy、hs-CRP水平>SAP组>对照组(F=1 651.746、132.115、86.942,P=0.000);高危亚组的BNP、Hcy及hs-CRP水平>中危亚组>低危亚组(F=593.394、15.026、9.031,P=0.000);不同TIMI危险评分的ACS患者三支病变率比较差异有统计学意义,高危亚组三支病变率>低危亚组>中危亚组(χ2=10. 097,P<0.01); ACS患者BNP、Hey及hs-CRP水平与TIMI危险评分均呈正相关(r=0. 692、0. 646、0. 530,P<0. 01)。结论 ACS患者BNP、Hcy及hs-CRP水平与TIMI危险评分均呈正相关,3个指标对ACS患者病情严重程度有一定的预测价值。
Objective The levels of B-type natriuretic peptide (BNP),homocysteine (Hcy) and high-sensitivity C-reactive protein c in patients with acute coronary syndrome (ACS) were measured,and their correlation with the risk score of thrombolytic therapy for myocardial infarction (TIMI) was analyzed. Methods Ninety ACS patients treated in the third Cardiovascular Medicine Department of Shengjing Hospital affiliated to China Medical University from January to December 2017 were selected as ACS group. According to TIMI risk score,they were divided into high-risk subgroup (33 cases),middle-risk subgroup (30 cases) and low-risk subgroup (27 cases). Another 40 patients with stable angina pectoris (SAP) who received treatment in the same period were selected as ACS group. For SAP group,40 volunteers with normal coronary angiography were taken as control group. The levels of BNP,Hcy and hs-CRP in each group were compared,and the relationship between TIMI risk score and pathological branches of ACS patients was analyzed. The correlation between the levels of BNP,Hcy and hs-CRP in ACS patients and TIMI risk score was also analyzed. Results The levels of BNP,Hcy and hs-CRP in ACS group > SAP group > control group (F = 1 651. 746,F = 132. 115,F = 86. 942,P = 0. 000); the levels of BNP,Hcy and hs-CRP in high-risk subgroup > middle-risk subgroup > low-risk subgroup (F = 593. 394,F = 15. 026,F =9. 031,P = 0. 000); the rates of three lesions in ACS patients with different TIMI risk scores had significant differences,with high-risk subgroups (F = 593. 394,F = 15. 026,F = 9. 031,P = 0. 000). There was a positive correlation between the levels of BNP,Hcy and hs-CRP in ACS patients and TIMI risk scores (r = 0. 692,r = 0. 646,r = 0. 530,P < 0. 01). Conclusion The levels of BNP,Hcy and hs-CRP in ACS patients were positively correlated with TIMI risk score,and the three indicators had certain predictive value for the severity of ACS patients.
作者
王少君
庞文跃
任丽
郭思聪
WANG Shaojun;PANG Wenyue;REN Li;GUO Sicong(Department of Cardiovascular Medicine,Shengjing Hospital of China Medical University,Liaoning Province,Shenyang 110004,China)
出处
《疑难病杂志》
CAS
2018年第12期1306-1310,共5页
Chinese Journal of Difficult and Complicated Cases
基金
辽宁省科学技术计划项目(2015010235)
关键词
急性冠状动脉综合征
B型利钠肽
同型半胱氨酸
超敏C反应蛋白
心肌梗死溶栓危险评分
相关性
Acute coronary syndrome
B type natriuretic peptide
Homocysteine
Hypersensitivity C reactive protein
Thrombolytic risk score for myocardial infarction
Relevance
