摘要
目的:评价新疆乌鲁木齐市维吾尔族、汉族不同孕期孕妇碘营养状态和甲状腺功能状态及分析其变化规律。方法:采用横断面方法采集2016年1月至2017年9月在新疆自治区人民医院内分泌科筛查甲状腺功能的孕妇进行研究,检测尿碘及甲功,最终资料完整的常住健康单胎孕妇1268例进入分析,其中主要的4个民族:汉、维吾尔、回、哈萨克共1261人做进一步民族间比较。结果:(1)总人群尿碘中位数172.3μg/L,其中碘严重缺乏3.79%、缺乏36.99%、足量35.49%、超足量18.69%、过量5.05%。(2)尿碘的民族间比较发现汉族女性最高(182.95μg/L),维吾尔族最低(156.30μg/L),两两比较存在统计学差异(P=0.01),其他民族间对比无统计学差异。(3)各民族不同孕期尿碘水平未见统计学差异。(4)在汉族与维吾尔族孕早、中、晚期的血清TSH水平差异均有统计学意义[(3.57±2.93)vs.(5.13±7.12),P=0.000;(2.92±1.68)vs.(3.82±4.52),P=0.008;(2.70±1.31)vs.(3.62±1.85),P=0.000]。(5)尿碘与TSH无明确相关性。结论:乌鲁木齐妊娠期女性碘营养状态总体适宜,但仍然有40.77%的孕妇存在碘缺乏,维吾尔族女性碘缺乏更明显;汉族女性各孕期TSH均低于维吾尔族女性,该结果与同期本地自然人群调查结果不同;尿碘与TSH之间无相关性。
Objective:To investigate the iodine nutrition status and thyroid function and their changes in different stages of pregnancy among pregnant Uygur and Han women in Urumqi,China. Methods:The cross-sectional method was used to assess the pregnant women who underwent thyroid function screening in Department of Endocrinology in The People’s Hospital of Xinjiang Autonomous Region from January 2016 to September 2017,and urinary iodine and thyroid function were evaluated. A total of 1268 healthy pregnant women with a single fetus who had complete clinical data were enrolled,among whom 1261 Han,Uygur,Hui,and Kazakh pregnant women were included for further comparison between different ethnic groups. Results:The median urinary iodine of all women was 172.3 μg/L,and of all women,3.79% had severe iodine deficiency,36.99% had iodine deficiency,35.49% had sufficient iodine, 18.69% had super sufficient iodine,and 5.05% had excessive iodine. The Han women had the highest level of urinary iodine(182.95 μg/L),and the Uygur women had the lowest level(156.30 μg/L),with a significant difference between the two groups(P=0.01),while there was no significant difference between the other ethnic groups. There was no significant change in urinary iodine during the different stages of pregnancy in each ethnic group. There was a significant difference between the Han and Uygur groups in serum thyroid stimulating hormone(TSH)level in the first,second,and third trimesters(first trimester:3.57±2.93 vs. 5.13±7.12,P <0.001; second trimester:2.92±1.68 vs. 3.82±4.52,P=0.008;third trimester:2.70±1.31 vs. 3.62±1.85,P <0.001). There was no clear correlation between urinary iodine and TSH. Conclusion:There is good iodine nutrition status in pregnant women in Urumqi,but 40.77% of these women have iodine deficiency,and Uygur women have more serious iodine deficiency. Han women have a lower TSH level than Uygur women during each stage of pregnancy,which is different from the results of the local natural population during the same period of time. There is no correlation between urinary iodine and TSH.
作者
罗蕴之
邢淑清
辛亮
王新玲
郭艳英
Luo Yunzhi;Xing Shuqing;Xin Liang;Wang Xinling;Guo Yanying(Department of Endocrinology,People's Hospital of Xinjiang Uygur Autonomous Region)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2018年第12期1586-1590,共5页
Journal of Chongqing Medical University
基金
新疆维吾尔自治区人民医院院内资助项目(编号:20170315)
