摘要
目的根据社区健康维、汉居民血清Ⅰ型原胶原氨基端肽(procollagen type 1 N-terminal propeptied,P1NP)和Ⅰ型原胶原羧基端肽交联(βcorss-linked C-terminal telopeptide of typeⅠcollagen,β-CTX)浓度,按照不同民族、性别、年龄分层分析,建立骨转换指标的参考范围。方法选取2013年在乌鲁木齐市社区流行病学调查资料中1160例社区居民为研究对象,采用化学发光法检测血清P1NP和β-CTX的浓度,并同时检测骨代谢调节激素甲状旁腺激素及25羟维生素D水平。采用自动分析仪检测钙,磷,肝、肾功能,测量身体、体重并计算体量指数(BMI)。结果本项研究共纳入1160例维汉居民,平均年龄45. 34±14. 15(18～84)岁,其中维吾尔族449例(男性∶女性为130∶319,平均年龄41. 58±12. 07岁),汉族711例(男性∶女性为223∶488,平均年龄47. 71±14. 85岁);总人群血清P1NP及β-CTX的浓度中位数及95%CI分别为48. 88ng/ml(95%CI:22. 85～124. 20ng/ml)及0. 24ng/ml(95%CI:0. 08～0. 70ng/ml),按民族分层后,维汉血清P1NP及β-CTX均存在差异,进一步年龄及性别分层,分别以30～50岁(30～绝经前)作为男(女)性别参照标准,女性30岁～绝经前P1NP及β-CTX参考范围(维/汉:22. 67～92. 70ng/ml,0. 08～0. 63ng/ml及20. 55～92. 26ng/ml,0. 06～0. 44ng/ml),男性30～49岁血清P1NP及β-CTX参考范围(维/汉:28. 66～107. 00ng/ml,0. 12～0. 81ng/ml及29. 35～96. 01ng/ml,0. 10～0. 56ng/ml),维、汉两个骨转换指标的中位数浓度差异均有统计学意义(P <0. 05); P1NP与β-CTX密切相关(r=0. 709,P <0. 01)。P1NP及β-CTX均与PTH呈正相关(r=0. 166,0. 228),与25(OH) D呈负相关(r=-0. 108,-0. 144,P <0. 01),PTH与25 (OH) D呈负相关(r=-0. 342,P <0. 01)。结论初步按年龄分组建立乌鲁木齐社区居民不同年龄段维、汉男女骨转换标志物的参考范围,维、汉血清P1NP及β-CTX水平存在民族差异。
Objective To investigate the serum Procollagen type 1N -terminal propeptiede(P1NP)and β corss -linked C -terminal telopeptide of type Ⅰ collagen(β-CTX)reference range in healthy community residents according to different ethnic,gender and age. Methods In May 2013,a total of 1160 subjects who received epidemilolgical survey of thyroid disorders with complete clinical data in a community of Urumqi were chosen as research subjects.Serum levels of P1NP,β-CTX,parathyroid hormone (PTH)and 25-hydroxyvitamin D [25(OH)D)]were measured by chemiluminescence assay.Serum levels of calcium,phosphorus,hepatic and renal function by automatic analyzer.Body and weight were meatured,body mass index (BMI)were calculated.Results A total of 1160 subjects of Han and Uygur with average age of 45.34±14.15years were enrolled,including 449 Uygur (male/female :130:319,41.58±12.07 years), 711 Han (male/female:223:488,47.71±14.85 years).The median of P1NP and β-CTX leves were 48.88ng/ml(95%CI:22.85-124.20)and 0.24ng/ml(95% CI:0.08-0.70).The age range 30 to 50(30 to menopause)was used when establishing BTM reference ranges in man or women.In women,95% confidence interval of serum P1NP and β-CTX levels (Uygur/Han:22.67-92.70ng/ml, 0.08-0.63ng/ml and 20.55-92.26ng/ml,0.06-0.44ng/ml),In men,95%confidence interval of serum P1NP and β-CTX levels (Uygur/Han:28.66-107.00ng/ml,0.12-0.81ng/ml and 29.35-96.01ng/ml,0.10-0.56ng/ml).The median concentrations of two bone turnover indexes in Uygur and Han were different (P <0.01).P1NP and β-CTX were positively linearly correlated (r =0.709,P <0.01).PI NP and β-CTX correlated positively (r=0.166 and 0.228,P <0.01)with PTH,and negatively (r =-0.108,-0.144, P<0.01)with25(OH)D.PTHeorrelatedpositively (r=0.054,P<0.01)with25(OH)D.Conclusion Based on the age ,gender and nationality,the reference ranges for P1NP and β-CTX were established in Urumqi.There are ethnic differences in bone turnover markers between Uygur and Han nationality.
作者
张凯迪
孙楠
王新玲
邢淑清
李素丽
努荣古丽.买买提
张洁
罗蕴之
陈园
赵红丽
袁欣
郭艳英
Zhang Kaidi;Sun Nan;Wang Xinling(Department of Endocrinology,People's Hospital of Xinjiang Uyghur Autonomous Region,Xinjiang 830001,China)
出处
《医学研究杂志》
2018年第11期115-120,共6页
Journal of Medical Research
基金
新疆维吾尔自治区乌鲁木齐市科学技术局基金资助项目(G161310003)
