摘要
目的:评估疏肝健脾法对桥本甲状腺炎干预的疗效。方法:将76例患者随机分为2组各38例,对照组给予口服优甲乐,研究组在对照组基础上给予疏肝健脾方。均治疗3月。观察甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)、促甲状腺激素(TSH)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血清总胆固醇(TC),同时记录甲状腺肿大程度,评估疗效、复发率。结果:治疗后,2组TSH、TMAb、TGAb较治疗前均下降(P <0.05),研究组TMAb、TGAb低于对照组(P <0.05)。2组TC、LDL-C均下降,且研究组TC、LDL-C水平低于对照组(P <0.05);2组HDL-C均上升,且研究组HDL-C水平高于对照组(P <0.05)。治疗3月后,研究组甲状腺肿大的痊愈率为47.37%(18/38),显著低于对照组的18.42%(7/38)(P <0.05)。研究组停药半年后亚临床甲减的复发率16.67%(3/18)显著低于对照组71.43%(5/7)(P <0.05)。结论:优甲乐联合疏肝健脾方有利于改善肝郁脾虚型桥本甲状腺炎患者的甲状腺功能、外周血血脂水平,提高临床疗效。
Objective:To evaluate the clinical effect of liver-smoothing and spleen-invigorating method intervening Hashimoto's thyroiditis. Methods:Divided 76 cases of patients into two groups randomly,38 cases in each group. The control group received the oral administration of Euthyrox,while the research group additionally received liver-smoothing and spleen-invigorating prescription. The treatment for both groups lasted for 3 months. Observed the levels of thyroglobulin antibody (TGAb), thyroid microsomal antibody (TMAb),thyroid stimulating hormone(TSH),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and serum total cholesterol (TC), recorded the degree of thyroid enlargement, and valuated the clinical effect and recurrence rate. Results:After treatment,the levels of TSH,TMAb and TGAb in both groups were lower than those before treatment(P<0.05),and the levels of TMAb and TGAb in the research group were lower than those in the control group(P<0.05). The levels of TC and LDL-C in both groups were decreased,and the levels of TC and LDL-C in the research group were lower than those in the control group(P < 0.05);the level of HDL-C in both groups was increased respectively,and the level of HDL-C in the research group was lower than that in the control group(P<0.05). After treatment for 3 months,the cure rate of thyroid enlargement was 47.37%(18/38) in the research group, being significantly higher than 18.42% (7/38) in the control group (P<0.05). After drug withdrawal for half a year, the recurrence rate of subclinical hypothyroidism was 16.67%(3/18) in the research group,being significantly lower than 71.43%(5/7) in the control group(P<0.05). Conclusion:Euthyrox combined with liver-smoothing and spleen-invigorating prescription helps to improve the thyroid function and the level of lipid in peripheral blood of patients with Hashimoto's thyroiditis of liver-depression and spleen-deficiency type,thus to enhance the clinical effect.
作者
曹飞燕
陈霞波
CAO Feiyan;CHEN Xiabo
出处
《新中医》
CAS
2018年第12期107-109,共3页
New Chinese Medicine
关键词
桥本甲状腺炎
疏肝健脾法
优甲乐
中西医结合疗法
Hashimoto's thyroiditis
Liver-smoothing and spleen-invigorating method
Euthyrox
Integrated Chinese and westernmedicine therapy
