摘要
目的观察逍遥丸对肝郁雄性大鼠性激素及神经递质的影响。方法采用"夹尾激怒法"复制大鼠模型,灌胃逍遥丸后,观测各组大鼠血清睾酮(T)、雌二醇(E2)、卵泡刺激素(FSH)含量及褪黑素(MT)含量;下丘脑五羟色胺(5-HT)含量。结果与空白组比较,模型组大鼠下丘脑组织5-HT降低(P<0.01),血清T、E2含量显著降低(P<0.01),FSH含量显著升高(P<0.05),MT含量显著升高(P<0.01);与模型组比较,逍遥丸组大鼠5-HT显著性升高(P<0.05),逍遥丸组大鼠血清T、E2含量显著升高(P<0.05),FSH含量显著降低(P<0.05),MT显著性降低(P<0.01)。结论逍遥丸可明显改善肝郁雄性大鼠血清性激素水平及MT含量,并可调节脑内单胺类神经递质5-HT含量变化。
Objective To observe the influence of Xiaoyao pills on 5-hydroxytryptamine (5-HT),melatonin and sex hormones in male rats with liver-qi stagnation.Methods 40healthy male Wistar rats were randomly divided into normal control group,model group,model and Xiaoyao pills group.The serum levels of testosterone (T),estradiol (E2),follicle stimulating hormone (FSH),melatonin (MT)and hypothalamic serotonin (5-HT)were measured after Xiaoyao pills were administered to rats.Results The content of MT in the brain of model group was higher compared with normal group and FSH was sharply increasing,5-HT was decreasing,serum T and E2were sharply decreasing.The content of MT in the brain of Xiaoyao pills group was sharply decreasing compared with normal group and 5-HT was sharply increasing,FSH was decreasing,serum T and E2 were sharply decreasing.Conclusion Xiaoyao pills can distinctively change the content of 5-hydroxytryptamine, melatonin and sex hormones in male rats with liver-qi stagnation.
作者
萧闵
何曦
周艳艳
徐建民
袁芳
XIAO Min;HE Xi;ZHOU Yanyan;XU Jianmin;YUAN Fang(Hubei University of Chinese Medicine,Wuhan 430065;672Orthopedics Hospital of Integrated Chinese-western Medicine,Wuhan 430070)
出处
《湖北中医药大学学报》
2018年第5期18-21,共4页
Journal of Hubei University of Chinese Medicine
基金
国家自然科学基金资助(项目编号:81102529)
国家中医药管理局全国名老中医药专家传承工作室建设项目(项目编号:[2014]-20)
湖北中医药大学2017年青苗计划(项目编号:2017ZZX030)
