摘要
目的优化蒸(煮)川乌的炮制工艺。方法以川乌中6种乌头类生物碱的含量作为评价指标,采用正交设计法考察川乌蒸法中浸泡时间、蒸制功率、蒸制时间;煮法中浸泡时间、煮制水量、煮制时间对炮制工艺的影响,确定川乌最佳的蒸(煮)工艺。结果最佳炮制工艺参数:川乌蒸制:浸泡软化62h,于600W下蒸5h;川乌煮制:浸泡软化48h,加水1400mL煮7h。结论经优化的炮制方法炮制后的制川乌单酯型生物碱与双酯型生物碱的含量相对稳定,明确2015版药典川乌炮制条件的参数,规范川乌的炮制方法,保障制川乌工业化生产质量的稳定。
Objective To optimize the processing technology of steaming (or boiled)monkshood.Methods Taking the content of six aconite alkaloids in Aconitum Aconitum as evaluation index,the orthogonal design method was used to investigate the effects of soaking time,steaming power,steaming time,or soaking time,water quantity and boiling time on the processing technology ofAconitum aconitum.Results The optimum processing parameters were as follows:Sichuan aconite steaming: soaking and softening for 62h,steaming for 5h at 600 W;Sichuan aconite steaming:soaking and softening for 48h,adding water for 1400mL for 7h.Conclusion The content of monoester alkaloids and diester alkaloids in Radix Aconiti Preparata prepared by optimized processing method is relatively stable,the parameters of processing conditions of Radix Aconiti Preparata in 2015 Pharmacopoeia are defined,the processing method of Radix Aconiti Preparata is standardized,and the quality of industrial production of Radix Aconiti Preparata is guaranteed.
作者
代堃
孟凡
王月
田楠楠
白杰
窦志英
王晖
周乐华
张超
DAI Kun;MENG Fan;WANG Yue;TIAN Nannan;BAI Jie;DOU Zhiying;WANG Hui;ZHOU Yuehua;ZHANG Chao(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;Tianjin Key Laboratory of Chinese Medicine Pharmacology,Tianjin 300193;Tianjin Chinese Medicine Slice Factory Co.,Ltd, Tianjin 300110;First Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300112)
出处
《湖北中医药大学学报》
2018年第6期48-52,共5页
Journal of Hubei University of Chinese Medicine
基金
天津市自然科学基金(项目编号:17JCYBJC28900)
科技基础性工作专项(项目编号:2014FY111100)
关键词
川乌
蒸制工艺
煮制工艺
正交设计
乌头碱
monkshood
steaming technology
boiling technology
orthogonal design
aconitine
