摘要
原发性高血压的发生机制复杂,由环境和遗传因素综合作用所致。近年来随着分子生物学技术的发展,高血压病的研究进入了基因检测时代,越来越多的研究表明,长链非编码RNA(LncRNA)与高血压病有着密切的联系,LncRNA能精确化调控基因表达,在细胞分化,生物发育及疾病发生发展过程中发挥巨大作用,随着对高血压作用机制及预防治疗的进一步研究,LncRNA将成为高血压诊断的新的生物学标记,现就LncRNA在原发性高血压的研究现状进行综述。
The mechanism of the occurrence of essential hypertension is complex and is caused by a combination of environmental and genetic factors.In recent years,with the development of molecular biology technology,the study of hypertension has entered the era of genetic testing.More and more research showed that long-chain non-coding RNA (LncRNA) was closely related to hypertension,and LncRNA could be precisely.The regulation of gene expression plays an important role in the process of cell differentiation,biological development and disease development.With the further study on the mechanism of action and prevention and treatment of hypertension,LncRNA will become a new biological marker for the diagnosis of hypertension.The current research status of LncRNA in essential hypertension is reviewed.
作者
谢青
杨锐
王利红
江华
毛玉娟
王莉
伊琳
XIE Qing;YANG Rui;WANG Lihong;JIANG Hua;MAO Yujuan;WANG Li;YI LING(Gansu University of Traditional Chinese Medicine,Lanzhou,730000, China)
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2018年第12期1235-1239,共5页
Journal of Clinical Cardiology
基金
国家自然科学基金项目(No:81460669)
