摘要
目的:探讨比较汉族、蒙古族、维吾尔族、哈萨克族4个不同民族丙戊酸血药浓度监测结果的差异。方法:采用回顾性研究方法,对某院282例次丙戊酸血药浓度监测结果按民族进行统计分析。结果:丙戊酸在汉、蒙、维、哈4个民族中浓度低于有效血药浓度的占比分别为28.81%,50.00%,45.68%,51.16%,在有效浓度范围内的占比分别为60.17%,45.00%,48.15%,41.86%,高于有效血药浓度的占比分别为11.02%,5.00%,6.17%,6.98%。结论:丙戊酸代谢在不同人群中存在民族差异,在同民族中也存在个体差异,使用丙戊酸盐进行个体化治疗时最好进行血药浓度监测,以便达到更好的临床疗效。
OBJECTIVE To explore the differences in blood concentrations of valproic acid between the Han,Mongolian,Uygur and Kazak ethnic groups.METHODS A retrospective study was used to statistically analyze the monitoring results of valproic acid in 329blood samples by ethnic groups.RESULTS The proportions of valproic acid in the four ethnic groups of Han,Mongolia,Uygur,and Kazak were lower than the effective plasma concentrations,accounting for 28.81%,50.00%,45.68%,and 51.16%,respectively.The percentage of valproic acid in the effective concentration range was 60.17%,45.00%,48.15%,41.86%,and the proportions higher than the effective blood concentration were 11.02%,5.00%,6.17%,6.98%,respectively.CONCLUSION Valproic acid has different metabolism in different populations,and individual differences even in the same ethnic group.Valproic acid salt for individualized treatment is best for blood concentration monitoring to achieve better clinical efficacy.
作者
冯荣
朱文陟
张凯军
FENG Rong;ZHU Wen-zhi;ZHANG Kai-jun(Department of Pharmacy,Renmin Hospital of Mongolian Autonomous Prefecture of Bortala,Xinjiang Bole 833400, China)
出处
《中国医院药学杂志》
CAS
北大核心
2018年第24期2518-2521,共4页
Chinese Journal of Hospital Pharmacy
基金
新疆维吾尔自治区自然科学基金(编号:2016D01A010)
关键词
民族
丙戊酸钠
血药浓度监测
基因
个体差异
ethnic group
valproic acid
blood concentration monitoring
gene
individual differences
