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丁苯酞注射液联合丹红注射液治疗急性脑梗死60例 被引量:20

Treatment of acute cerebral infarction with butylphthalide injection combined with Danhong injection in 60 patients
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摘要 目的:研究丁苯酞注射液联合丹红注射液在治疗急性脑梗死患者中的临床疗效及安全性评价。方法:选择急性脑梗死患者121例,按随机数字法分为2组,试验组(B+D) 60例,对照组61例,两组患者均给予常规的急性缺血性脑卒中方案治疗:抗血小板聚集、降脂稳定斑块、控制血压血糖、营养神经等。对照组在常规治疗的基础上加用丹红注射液30 m L加入0. 9%氯化钠注射液250 m L,静脉滴注,qd。试验组在对照组基础上联用丁苯酞注射液100 m L,静脉滴注,bid。两组患者均持续治疗14 d。比较两组患者的临床疗效,治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分及高敏C-反应蛋白(hs-CRP),血管内皮生长因子(VEGF)水平的变化以及药物不良反应的发生情况。结果:治疗后,试验组的总有效率为91. 67%,显著高于对照组的77. 05%,差异有统计学意义(P <0. 05)。治疗后两组患者的NIHSS评分、hs-CRP水平显著下降,其中试验组下降更为明显,差异有统计学意义(P <0. 05),治疗后两组患者的VEGF水平显著增高,其中试验组升高更为明显,差异有统计学意义(P <0. 05)。试验组出现的药物不良反应为牙龈出血和皮疹,对照组发生的药物不良反应为牙龈出血,且两组药物不良反应差异无统计学意义(3. 33%vs 3. 27%,P> 0. 05)。结论:丁苯酞注射液联合丹红注射液组治疗急性脑梗死的临床疗效显著,能够有效地减轻脑梗死后的炎症反应,促进局部血管的再生,减轻神经细胞的损伤,保护缺血的脑组织,且安全性良好。 Objective:To explore the efficacy and safety of butylphthalide injection combined with Danhong injection (B +D)in the treatment of patients with acute cerebral infarction.Methods:Totally 121 patients with acute cerebral infarction were randomly divided into B +D (n =60)and control (n =61 )groups. Symptomatic treatment including antiplatelet,lipid lowering,control blood pressure and blood glucose,nerve nutrition were administered in the two groups.On the base of the therapy,Danhong injection was treated (control group)or in combination with butylphthalide injection 100mL,bid,intravenous drip (B+D group).All patients in two groups were treated for 14 days.National institute of health stroke scale (NIHSS)score,clinical efficacy,the levels of hs-CRP and VEGF,incidence'of adverse drug reactions were compared before and after the treatment. Results:After treatment,the total effective rates were 91.67%and 77.05%in B +D and control groups,the total effective rates in B+D groups were significantly higher than those in control groups (P <0.05),respectively. After treatment,the NIHSS scores and the levels of hs-CRP were significantly lower (P <0.05)and the levels of VEGF were significantly higher (P<0.05)in B +D group than in control group.The adverse drug reactions were gingival bleeding and rash in B +D group,and gingival bleeding in the control group.The incidence of adverse drug reactions had no statistically significant difference between two groups (3.33%vs 3.27%,P >0.05).Conclusion:Butylphthalide injection combined with Danhong injection is effective in the treatment of acute cerebral infarction.It can effectively reduce inflammatory reaction and promote local angiogenesis after cerebral ischemia,so as to protect brain tissues from ischemic injury.
作者 余芬 YU Fen(Department of Neurology,Tongren Hospital of Wuhan University,Wuhan Third Hospital,Wuhan 430060,China)
出处 《中国新药杂志》 CAS CSCD 北大核心 2018年第24期2901-2904,共4页 Chinese Journal of New Drugs
关键词 丁苯酞注射液 丹红注射液 脑梗死 高敏C-反应蛋白 血管内皮生长因子. butylphthalide injection Danhong injection acute cerebral infarction hs-CRP VEGF
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