摘要
目的:观察乌蛇荣皮汤治疗糖尿病皮肤瘙痒症的临床疗效。方法:选取2016年9月至2017年8月在本院门诊及住院治疗,符合纳入标准的糖尿病皮肤瘙痒症患者40例,根据随机数字表法分为治疗组和对照组,每组20例。所有患者均给予基础降糖治疗,对照组给予氯雷他定片口服治疗,治疗组在对照组治疗的基础上加用乌蛇荣皮汤治疗。观察治疗前后两组患者中医证候积分、瘙痒视觉模拟评分法(visual analogue scale,VAS)评分及P物质(substance P,SP)、组胺含量的变化。结果:治疗后,两组中医证候积分、VAS评分均优于治疗前(P <0. 01),并且治疗组改善程度优于对照组(P <0. 01,P <0. 05);两组治疗后SP、组胺含量均较治疗前降低,差异均有统计学意义(P <0. 01),并且治疗组改善程度优于对照组(P <0. 01)。结论:乌蛇荣皮汤治疗糖尿病皮肤瘙痒症具有良好的临床疗效,能明显改善患者瘙痒程度,同时也能调节SP及组胺的含量。
Objective: To observe the clinical curative effect of Wusna Rongpi Decoction( WSRPD) on diabetic skin pruritus.Methods: Forty patients with diabetic pruritus who met the inclusion criteria were treated in our hospital from September 2016 to August 2017 and selected. They were divided into the treatment group and the control group according to random number table method,with 20 cases in each group. The treatment group consisted of 20 cases. All the patients were given basic hypoglycemic treatment,the ones in the control group were given oral Loratadine Tablets,and the ones in the treatment group were treated with WSRPD on the basis of the control group. The changes of TCM syndrome score,visual analogue scale( VAS) score,substance P( SP) and histamine content before and after the treatment were observed. Results: After the treatment,the scores of TCM syndromes and VAS in the two groups were better than those before the treatment( P < 0. 01),and the improvement degree of the treatment group was better than that of the control group( P < 0. 01,< 0. 05). After the treatment,the contents of SP and histamine in the two groups were lower than those before the treatment,and the differences were statistically significance( P < 0. 01),and the improvement degree of the treatment group was better than that of the control group( P < 0. 01). Conclusion: WSRPD has a remarkable clinical curative effect on diabetic skin pruritus,can significantly improve the itching degree of patients,and also regulate the content of SP and histamine.
作者
齐辉
陈叶
QI Hui;CHEN Ye(Shenzhen Longhua District Central Hospital,Shenzhen,Guangdong,China,518000)
出处
《河南中医》
2018年第12期1879-1881,共3页
Henan Traditional Chinese Medicine
基金
深圳市科技计划项目(编号:JCYJ201604281809-24481
JCYJ2015040116384-1053)
关键词
糖尿病
皮肤瘙痒症
乌蛇荣皮汤
瘙痒
diabetes mellitus
Skin pruritus
Wusna Rongpi Decoction (WSRPD )
pruritus
