摘要
目的:观察复肾降浊胶囊治疗慢性肾功能衰竭患者的临床疗效,及对患者血红蛋白(hemoglobin,Hb)、C反应蛋白(C-reaction protein,CRP)及24小时尿蛋白定量(24-hour urine protein,24hUP)的影响。方法:160例慢性肾功能衰竭患者随机平均分为观察组和对照组。对照组在常规西医治疗基础上服用肾衰宁颗粒;观察组在常规西医治疗基础上服用复肾降浊胶囊,两组观察时间均为45 d。比较两组患者临床疗效,Hb、CRP及24hUP水平。结果:观察组有效率为86. 25%,对照组为77. 50%,两组有效率比较,差异有统计学意义(P <0. 05)。两组患者治疗后中医证候积分均显著低于治疗前,观察组治疗后显著低于治疗前,差异均有统计学意义(P <0. 05)。观察组治疗后Hb高于治疗前,CRP、24hUP均低于治疗前,差异均有统计学意义(P <0. 05)。与对照组比较,观察组治疗后血Hb升高,血CRP及24hUP均显著降低,差异均有统计学意义(P <0. 05)。结论:复肾降浊胶囊治疗慢性肾功能衰竭患者临床疗效显著,并能够改善患者贫血状态、降低微炎症反应及24hUP水平。
Objective: To observe the clinical efficacy of Fushen Jiangzhuo Capsule in treatment of patients with chronic renal failure,and the effect on hemoglobin( Hb),C-reaction protein( CRP) and 24-hour urine protein quantitation( 24 hUP). Methods:160 patients with chronic renal failure were randomly divided into observation group and control group. The control group took Shenshuaining Granules on the basis of conventional western medicine treatment; the observation group took Fushen Jiangzhuo capsule on the basis of conventional western medicine treatment. The observation time lasted for 45 days. The clinical efficacy,Hb,CRP and 24 hUP levels were compared between the two groups. Results: The effective rate of the observation group was 86. 25%,and that of the control group was 77. 50%. The difference of the effective rate of the two groups was statistically significant( P <0. 05). The scores of TCM syndromes in the two groups were significantly lower than those before treatment. That of the observation group was significantly lower than that before treatment,and the difference was statistically significant( P < 0. 05). The Hb of the observation group was higher than that before treatment,and the CRP and 24 hUP were lower than before treatment,and the differences were statistically significant( P < 0. 05). Compared with that of the control group,the blood Hb increased,blood CRP and24 hUP decreased significantly in the observation group,and the difference was statistically significant( P < 0. 05). Conclusion:Fushen Jiangzhuo Capsule is effective in treatment of patients with chronic renal failure,which can improve the anemia status,reduce microinflammation and 24 hUP.
作者
邢海燕
张琳琪
张国胜
任永朋
段明亮
XING Haiyan;ZHANG Linqi;ZHANG Guosheng;REN Yongpeng;DUAN Mingliang(The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000;Zhengzhou TCM Hospital,Zhengzhou Henan China 450007;The Affiliated Hospital to Henan Academy of Traditional Chinese Medicine,Zhengzhou,Henan China 450004)
出处
《中医学报》
CAS
2018年第12期2445-2448,共4页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2013ZY02062)
关键词
复肾降浊胶囊
慢性肾功能衰竭
血红蛋白
C反应蛋白
24小时尿蛋白定量
中西医结合
Fushen Jiangzhuo Capsule
chronic renal failure
hemoglobin
C-reactive protein
24-hour urine protein quantification
Integrative medicine
