摘要
手足口病(hand,foot and mouth disease,HFMD)是儿童常见的急性传染病。肠道病毒71型(enterovirus,EV71)是HFMD的主要病原体之一,在我国HFMD的发病率较高,主要感染对象是婴幼儿,EV71感染也是目前导致HFMD重症患儿的最主要的病原体。我国于2008年5月2日将HFMD列为丙类法定传染病。HFMD的致病机理尚未明确,目前还未研发出能够有效治疗此类病毒的药物。EV71中的非结构蛋白3D能够催化病毒基因组的复制和转录,是开发抗EV71病毒药物的重要靶标之一。本文就EV713D蛋白的结构、功能作一综述,为抗病毒药物的研发提供参考。
Hand, foot and mouth disease (HFMD) is a common acute infectious disease among children. Enterovirus 71 (EV71) is one of the major pathogens of HFMD. The incidence of HFMD in our country is higher, the main target population of infection is infants and young children; EV71 is also the most important pathogen causing severe HFMD in children currently. HFMD was classified as notifiable communicable disease of Category C on May 2, 2008. Pathogenesis of HFMD is not yet clear, and there is no drug that can treat such virus effectively. The non-structural protein 3D in EV71, is one of the important targets for the development of anti-EV71 virus drugs, which catalyzes the replication and transcription of the viral genome. This review provides a summary of the structure and function of EV71 3D, which can provide reference for the development of antiviral drugs.
作者
温小菁
陶泽新
温红玲
Wen Xiaojing;Tao Zexin;Wen Hongling(Department of Laboratory Microbiology,School of Public Health,Shandong University,Jinan 250012, China;Shandong Center for Disease Control and Prevention)
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2018年第6期659-663,共5页
Chinese Journal of Experimental and Clinical Virology
基金
山东省自然科学基金面上项目(ZR2018MH035)
山东省传染病预防控制重点实验室开放课题(2017KEYLAB02).
关键词
手足口病
肠道病毒71型
3D蛋白
Hand, foot and mouth disease
Enterovirus 71
3D protein
