摘要
目的了解妊娠女性妊娠前及妊娠期钙摄入水平与早产的相关性,为早产的有效干预提供科学依据。方法以在甘肃省妇幼保健院长期就诊并随访到分娩结局的正常孕妇为研究对象,以非条件Logistic回归模型分析补充钙剂及膳食钙摄入水平与早产的关系。结果在控制相关混杂因素后,妊娠前及/或妊娠期服用钙补充剂>3个月使早产的发生风险降低14%(OR=0.86,95%CI=0.77~0.96),且存在剂量反应关系(P<0.05)。按妊娠期分层后,妊娠晚期补充钙剂是早产的保护因素(OR=0.75,95%CI=0.62~0.92),类似的保护作用对早期与极早期早产(<32孕周)较为显著。将膳食钙摄入水平量化分层后,妊娠期平均膳食钙摄入>465.55mg/d使早产的发生风险显著下降(OR=0.66,95%CI=0.53~0.82,P<0.05),类似的保护作用对不同程度早产、干预性早产及自发性早产均有不同程度体现。结论妊娠前及妊娠期适量补钙或增加膳食钙摄入水平可降低早产的发生风险,类似的保护作用在妊娠晚期更显著。
Objective To study the association of maternal calcium supplementation and dietary calcium intake with the preterm birth so that to provide scientific basis for effective intervention of preterm birth.Methods Normal pregnant women who were followed up all through to childbirth in Gansu Provincial Maternity and Child Care Hospital were selected.Multivariate logistic regression was used to evaluate the association of calcium supplementation and intake with preterm birth.Results After confounding factors were adjusted,pregnant women who took calcium supplement for more than 3 months before and/or during pregnancy had the risk of preterm birth reduced by 14% which was dose-responding(OR=0.86,95% CI=0.77-0.96,P<0.05).Through stratifying by trimesters of pregnancy,it was found that calcium supplement in the third trimester was a protective factor for preterm birth and especially significant in early and very early pregnancy(OR=0.75,95% CI=0.62-0.92,P<0.05).Through stratifying by dietary calcium intake,pregnant women who took dietary calcium more than 465.55 mg/d had the risk of preterm birth significantly reduced which was shown by the reduction of preterm birth of different degrees,controlled preterm labor and spontaneous premature dilivery(OR=0.66,95% CI=0.53-0.82,P<0.05).Conclusion Appropriate calcium supplementation or dietary calcium intake before and during pregnancy can reduce the risk of preterm birth,which is especially significant in late pregnancy.
作者
邵亚雯
白岩
蔺茹
何文华
苏怀烨
邱伟涛
毛宝宏
Shao Yawen;Bai Yan;Lin Ru;He Wenhua;Su Huaiye;Qiu Weitao;Mao Baohong
出处
《中华临床营养杂志》
CAS
CSCD
2018年第5期272-277,共6页
Chinese Journal of Clinical Nutrition
基金
甘肃省自然科学研究基金计划(1208RJZA122)
中疾控妇幼中心合生元母婴营养与健康研究项目(2018FYH007).
关键词
钙
早产
妊娠晚期
流行病学
Calcium
Preterm birth
Late pregnancy
Epidemiology
