摘要
目的探讨癌胚抗原(CEA)、铁蛋白(FER)、鳞状细胞癌相关抗原(SCC)、糖链蛋白125(CA125)和糖链蛋白19-9(CA19-9)、神经烯醇化酶(NSE)和细胞角质蛋白19的片断(CY21-1) 7项肿瘤标志物对肺癌的诊断价值。方法检测33例肺部良性疾病病例和538例肺癌病例(腺癌340例,鳞癌150例,小细胞癌48例) 7项肿瘤标志物的水平。结果肺癌组和肺良性疾病组比较,血清中FER水平差异无统计学意义(P=0. 285),其他6项血清肿瘤标志物差异均有统计学意义(P <0. 05);不同的病理类型肺癌组(腺癌、鳞癌、小细胞癌)和肺良性疾病组比较,血清CEA、CA125、NSE和CY21-1水平差异均有统计学意义(P <0. 05)。根据ROC曲线,肺腺癌没有特别优势的指标,AUC均<0. 70,适合联合检测;肺磷癌的首选指标是CY21-1,AUC为0. 909;小细胞肺癌首选NSE,AUC为0. 937。结论对于首诊的疑肺癌患者,建议对其进行血清标志物多项联合检测,此后再根据不同的病理类型进行选择性跟踪检测。
Objective To evaluate the diagnostic valve of CEA,FER and other tumor markers for lung cancer.Methods The levels of serum CEA,FEB,SCC,CA125,CA19-9,NSE and CY21-1 were detected in 33 cases of benign lung disease and 538 cases of lung cancer ( 340 eases of adenocarcinoma,150 cases of squamous cell carcinoma and 48 cases of small cell carcinoma).Results There was no statistical significance on the difference in serum FER level between lung cancer group and lung benign disease group (P =0.285).The differences of other six serum tumor markers were statistically significant (P < 0.05).Differences in serum levels of CEA,CA125,NSE and CY21-1 in lung cancer patients were statistically significant, compared with different pathological types (adenoearcinoma,squamous cell carcinoma,small cell carcinoma)and benign lung disease (P <0.05).According to ROC curve,lung adenocarcinoma has no particular advantage of the index and is suitable for joint detection,with AUC <0.70;the first index choice for lung squamous cell carcinoma was CY21-1,and AUC was 0.909; NSE was preferred to small cell carcinoma,and AUC was 0.937.Conclusion For the suspected lung cancer patients with primary diagnosis,it is recommended to conduct joint detection of serum markers,tracing and test according to different pathological types.
作者
王明丽
徐笑红
单绿虎
张毅敏
刘超
WANG Ming-li;XU Xiao-hong;SI-IAN Lv-hu;ZHANG Yi-min;LIU Chao(Clinical Laboratory,Zhejiang Cancer Hospital,Hangzhou,Zhejiang 310022,China)
出处
《中国卫生检验杂志》
CAS
2019年第1期1-3,共3页
Chinese Journal of Health Laboratory Technology
基金
国家高技术研究发展计划(863计划)子课题(2014AA-022304)
关键词
肺癌
肿瘤标志物
诊断价值
Lung cancer
Serum tumor markers
Diagnosis valve
