摘要
目的对比分析冠状动脉经皮介入术(PCI)中单纯静脉与冠状动脉联合静脉应用替罗非班对急性冠状动脉综合征(ACS)患者预后的影响。方法选取开封市人民医院2016年1月至2018年1月收治的ACS患者160例,根据随机数表法分为对照组与观察组,每组80例。对照组单纯静脉给予替罗非班,观察组则采取冠状动脉联合静脉给药,术前、术后24h,检测并对比两组患者心肌标志物[肌钙蛋白I(CTnI)、肌酸激酶同工酶(CK-MB)]变化情况、冠状动脉造影检查结果、超声心动图检查结果;术后随访6个月,记录并比较两组负性心血管事件发生情况。结果术后24h,观察组CTnI、CK-MB水平较术前降低幅度高于对照组,TIMI血流、左室射血分数(LVEF)水平高于对照组,帧计数(CTFC)低于对照组,差异有统计学意义(P<0.05)。术后随访6个月,观察组各负性心血管事件发生率低于对照组,差异有统计学意义(P<0.05)。结论PCI术中替罗非班以冠状动脉联合静脉方式给药,患者冠状动脉血流、左室收缩功能、心肌灌注改善情况较单纯静脉给药好,术后负性心血管事件发生率低,预后好。
ObjectiveTo comparatively analyze the effect of intravenous administration of tirofiban and boronary artery combined with intravenous administration of tirofiban in coronary percutaneous interention (PCI) on prognosis of acute coronary syndrome(ACS) patients.MethodsA total of 160 patients with ACS admitted in Kaifeng People's Hospital from January 2016 to January 2018 were selected, according to the random indicator method, they were divided into control group and observation group, with 80 cases in each group. In the control group, tirofiban was given intravenously, while the observation group was given coronary artery combined with intravenous administration of tirofiban. The changes of cardiac markers [troponin I (CTnI), creatine kinase isoenzyme (CK-MB)], coronary angiography and echocardiography were detected and compared between the two groups before and 24 hours after operation; After 6 months of follow-up, the negative cardiovascular events were recorded and compared between the two groups.ResultsAt 24 h after surgery, the CTnI and CK-MB levels decreased more significantly in the observation group than those in the control group, the levels of TIMI blood flow and LVEF were higher than those in the control group, and the CTFC was lower than that in the control group, there were significant differences (P<0.05). After 6 months of follow-up, the incidence of negative cardiovascular events in the observation group was lower than that in the control group, and the difference was significant (P<0.05).ConclusionsCoronary artery combined with intravenous administration of tirofiban during PCI operation, the improvement of coronary artery blood flow, left ventricular systolic function and myocardial perfusion is good compared with intravenous administration, and the postoperative negative incidence of cardiovascular events is low, and the prognosis is good.
作者
董凤霞
Dong Fengxia(Department of Cardiology,Kaifeng People's Hospital,Kaifeng 475002,China)
出处
《中国实用医刊》
2018年第22期105-107,111,共4页
Chinese Journal of Practical Medicine
