摘要
目的探讨新辅助化疗前MRI征象与新辅助化疗疗效的相关关系。方法回顾性分析2015年1月至2017年1月在浙江省中医院行新辅助化疗并取得术后常规病理结果的70例乳腺癌患者的临床病理资料及新辅助化疗前MRI资料,探讨其与术后病理缓解的关系。结果三阴型及Her-2型乳腺癌较易获得病理缓解。MRI图像上,病理缓解情况与病灶的数量(P=0.002)及动态增强后是否为肿块型强化(P=0.008)有关,与病灶大小、表观扩散系数(ADC)值、T2WI信号、淋巴结肿大及乳后间隙、时间信号曲线(TIC)无关。在肿块型强化乳腺癌中,肿块形状与病理缓解相关(P=0.043)。结论单灶型、肿块型强化且形态规则的乳腺癌易获得病理缓解。
Objective To explore the association between the pretreatment magnetic resonance imaging signs with the efficacy of neoadjuvant chemotherapy for breast cancer patient.Methods 70 patients with breast cancer who accepted the neoadjuvant chemotherapy in Zhejiang Provincal Hospital of TCM and got definited clinical and pathological data after surgery as well as the pretreatment DCE-MRI from January 2015 to January 2017 was retrospectively selected.The association between the signs of MRI before treatment with pathologic complete response situation was analyzed.Results Triple negative and Her-2 breast cancer subtype was easier to get pathologic complete response.Based on the MRI signs,the pathologic response situation was significantly higher in the unifocal and mass-like breast cancer(P=0.002,P=0.008,respectively).However,the size,ADC value,T2WI signal intensity,lymph node enlargement and retromammary space clearance,TIC curve type were not related to the pathologic response(P >0.05).Moreover,the shape of mass were related to the pathologic response(P=0.043).Conclusion Unifocal and regular mass-like breast cancer was more likely to get pathological response.
作者
周佳丽
刘玉凤
卜阳阳
周长玉
喻迎星
许茂盛
ZHOU Jiali;LIU Yufeng;BU Yangyang(The First Clinical Medical College of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2018年第12期1989-1993,共5页
Journal of Clinical Radiology
基金
浙江省卫生厅平台骨干项目(编号:2016147237)
浙江省中医药科学研究基金项目(编号:2018ZA037)
关键词
乳腺癌
病理缓解
磁共振成像
新辅助化疗
Breast cancer
Pathologic response
MRI
Neoadjuvant chemotherapy
