摘要
目的分析总结儿童横纹肌肉瘤(RMS)的18F-脱氧葡萄糖(FDG)PET/CT表现,探讨PET/CT在RMS中的诊断价值。方法回顾性分析2011年7月至2017年9月间29例经病理证实的RMS患儿(男15例,女14例,年龄1~14岁)的临床资料及18F-FDGPET/CT图像,分析PET/CT图像特点,计算并比较不同病理分型RMS的肿瘤/肝脏最大标准摄取值(SUVmax)比值(TLR),采用Mann-Whitneyu检验分析数据。结果29例患儿中,胚胎型RMS19例,腺泡状RMS7例,余3例分型不明。原发灶中位SUVmax为6.8(4.3,8.9)。胚胎型RMS和腺泡状RMS肿瘤中位SUVmax[6.2(4.3,8.8)与5.3(4.0,9.0)]和中位TLR[3.6(2.6,8.1)与3.0(2.2,6.3)]均未见明显差异(u值:60.00和48.50,均P>0.05)。15例患儿发现淋巴结病变,6例有肺部病变,4例患儿发现骨或骨髓腔病变,2例发现乳腺病变。结论18F-FDGPET/CT可以较好地反映RMS患儿病灶分布范围及其代谢活性,为临床诊疗提供依据。
Objective To summarize the 18F-fluorodeoxyglucose(FDG)PET/CT findings of pediatric rhabdomyosarcoma(RMS),and to explore the value of PET/CT in the diagnosis of RMS.Methods PET/CT images and clinical data of 29 RMS patients(15 males,14 females,age range:1-14 years)histopathologically confirmed from July 2011 to September 2017 were evaluated retrospectively.The imaging features were analyzed,and the maximum standardized uptake value(SUVmax)ratios of tumors to the liver(TLR)in different pathological types of RMS were calculated and compared.Mann-Whitney u test was used to analyze the data.Results There were 19 patients with embryonic RMS,7 with alveolar RMS,and 3 with unknown types.The median SUVmax of primary lesion was 6.8(4.3,8.9).There were no statistically significant differences in SUVmax(6.2(4.3,8.8)vs 5.3(4.0,9.0))and TLR(3.6(2.6,8.1)vs 3.0(2.2,6.3))between embryonic RMS and alveolar RMS(u values:60.00 and 48.50,both P>0.05).PET/CT detected lymph nodes lesions with increased metabolism in 15 patients,lung lesions in 6 patients,bone or bone marrow lesions in 4 patients and breast involvement in 2 patients.Conclusion 18F-FDG PET/CT can indicate the extent and metabolic activity of RMS,thus providing information for clinical practice.
作者
唐文芳
张建
王辉
Tang Wenfang;Zhang Jian;Wang Hui(Department of Nuclear Medicine,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092,China)
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2019年第1期6-9,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
