摘要
开发了一种通过钌(Ⅲ)催化的N-导向碳氢活化反应来直接合成羟甲基化芳烃衍生物的新方法.该方法的底物适用范围广泛,室温条件下即可以较高收率制得目标产物.为化学结构中含有羟甲基的生物活性化合物的合成提供了新的思路.
Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(Ⅲ)-catalyzed nitrogen atom directed C-H activation is described. The reaction proceeds smoothly at room temperature and generates the corresponding products in moderate to excellent yields. Meanwhile, it has a broad substrate scope and opens up an attractive avenue for the application of direct hydroxymethylation in the synthesis of biologically active compounds.
作者
张勇
杨中振
余昕玲
程旭
李伟剑
郭令妹
海俐
郭丽
吴勇
Zhang Yong;Yang Zhongzhen;Yu Xinling;Cheng Xu;Li Weijian;Guo Lingmei;Hai Li;Guo Li;Wu Yong(Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第12期3211-3218,共8页
Chinese Journal of Organic Chemistry
基金
supported by the National Natural Science Foundation of China(Nos.81373259,81573286,81602954)~~
关键词
碳氢活化
多聚甲醛
羟甲基化
室温
C-H activation
paraformaldehyde
hydroxymethylation
room temperature
