摘要
发展了两个基于硫叶立德骨架的亲电五氟乙基化试剂,其合成高效简洁、固体状态下稳定而溶液中反应活性高.在温和条件下,该试剂可以与β-酮酸酯、芳基/杂芳基碘化物以及富电子芳烃反应高产率地得到相应的五氟乙基化产物.
Two electrophilic pentafluoroethylating reagents of pentafluoroethyl(p-methylphenyl)sulfonium bis(carbometh- oxy)methylide (4a) and pentafluoroethyl(4-nitrophenyl)sulfonium bis(carbomethoxy)methylide (4b), and their reactions under mild conditions with β-ketoesters, aryl iodides and heteroaromatics are described.
作者
刘亚飞
葛航铭
吕龙
沈其龙
Liu Yafei;Ge Hangming;Lu Long;Shen Qilong(Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032;Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第1期257-264,共8页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.21625206,21632009,21572258,21572259,21421002)
the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)~~
关键词
氟
五氟乙基
硫叶立德
亲电
fluorine
pentafluoroethyl
sulfonium ylide
electrophilic
