摘要
目的:分析不同分子亚型乳腺癌患者动态增强磁共振成像(dynamic contrast enhanced-magnetic resonance imaging,DCE-MRI)定量参数变化。方法:选取2015年6月至2018年6月安阳市肿瘤医院收治的乳腺癌患者140例,均行乳腺DCE-MRI扫描,术后对切除病变进行常规病理及免疫组织化学检查,依据免疫组织化学结果分为4种不同分子亚型,对比不同分子亚型患者DCE-MRI定量参数[容量转移常数(K_(trans))、速率常数(K_(ep))、血管外细胞间隙容积比(V_e)]及血管生成情况[血管内皮生长因子(vascular endothelial growth factor,VEGF)、微血管密度(microvessel density,MVD)]的差异,分析其相关性。结果:Luminal A型、Luminal B型的K_(trans),K_(ep)低于三阴型、HER-2过表达型;Luminal A型、Luminal B型、HER-2过表达型的V_e高于三阴型,差异均有统计学意义(均P<0.05)。三阴型VEGF,MVD大于其他各分子亚型(P<0.05);相关性分析发现乳腺癌患者中三阴型的VEGF,MVD与K_(trans),K_(ep)呈正相关,与V_e呈负相关,Luminal A型、Luminal B型的MVD与K_(trans)呈正相关,与V_e呈负相关,HER-2过表达型的MVD与K_(trans)呈正相关(P<0.05)。结论:不同分子亚型乳腺癌患者DCE-MRI定量参数存在明显差异,且与患者血管生成存在密切关系,尤其在三阴型乳腺癌患者中这种相关性最明显。
Objective: To analyze the quantitative parameters of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) in patients with different molecular subtypes of breast cancer. Methods: A total of 140 patients with breast cancer who were admitted to the hospital during the period from June 2015 to June 2018 were enrolled. All patients underwent DCE-MRI scanning. The pathological and immunohistochemical examinations were performed on the resected lesions after surgery. The breast cancer was divided into four different molecular subtypes according to different molecular subtypes. Quantitative parameters of DCE-MRI [capacity transfer constant(Ktrans), rate constant(Kep), extravascular space to volume ratio(Ve)] and angiogenesis[vascular endothelial growth factors(VEGF), microvessel density(MVD)] were compared among different molecular subtypes and their correlations were analyzed. Results: The Ktrans and Kep of Luminal type A and Luminal type B were lower than those of triple negative type and HER-2 overexpression type. The Ve of the Luminal type A, Luminal type B and HER-2 overexpression type was higher than that of the three-negative type(all P<0.05). VEGF and MVD in patients with triple negative type were greater than those in patients with the other subtypes(P<0.05). Correlation analysis showed that VEGF and MVD were positively correlated with Ktrans and Kep, and negatively correlated with Ve in patients with triple negative breast cancer. MVD was positively correlated with Ktrans and negatively correlated with Ve in patients with Luminal A and Luminal B type breast cancer. MVD was positively correlated with Ktrans in patients with HER-2 overexpression type breast cancer(P<0.05). Conclusion: There are obvious differences in quantitative parameters of DCE-MRI between patients with different molecular subtypes of breast cancer, and they are closely related to angiogenesis in patients, especially in patients with triple negative breast cancer.
作者
王海彬
魏秋良
崔振华
WANG Haibin;WEI Qiuliang;CUI Zhenhua(Department of Imaging,Anyang Tumor Hospital,Anyang Henan 455000,China)
出处
《临床与病理杂志》
2018年第11期2453-2460,共8页
Journal of Clinical and Pathological Research
关键词
分子亚型
乳腺癌
动态增强磁共振成像
定量参数
molecular subtype
breast cancer
dynamic contrast enhanced-magnetic resonance imaging
quantitative parameters
