摘要
目的:通过研究艾灸对良性前列腺增生患者体内性激素和前列腺特异性抗原(prostate specific antigen,PSA)的影响,探讨艾灸治疗前列腺炎的相关机制。方法:采用艾条温和灸治疗良性前列腺增生患者25例,比较观察患者治疗前后的前列腺症状评分(IPSS)及生活质量指数评分(QOL),并采用化学发光法检测患者治疗前后体内睾酮、雌二醇、PSA表达水平。结果:艾灸治疗后患者临床症状明显减轻,生活质量明显提高,IPSS及QOL评分与治疗前比较,差异有统计学意义(P<0.01),且治疗后患者体内睾酮、雌二醇、睾酮/雌二醇明显升高(P<0.01或P<0.05),PSA含量明显降低(P<0.01)。结论:艾灸可以明显减轻良性前列腺增生患者的临床症状,提高其生活质量,其机制可能是通过提高睾酮、雌二醇及睾酮水平,同时降低其PSA水平。
Objective: To observe the effect of moxibustion on sex hormones and prostate specific antigen(PSA) in patients with benign prostatic hyperplasia, and to explore the mechanism of moxibustion in the treatment of prostatitis. Methods: Twenty-five patients with benign prostatic hyperplasia were treated with moxa stick moxibustion. The prostate symptom score(IPSS) and quality of life index score(QOL) were compared before and after treatment. The expression levels of testosterone, estradiol and PSA were detected by chemiluminescence method before and after treatment. Results: After moxibustion treatment, the clinical symptoms and quality of life of patients were significantly alleviated, and the scores of IPSS and QOL were significantly higher than those before treatment(P<0.01). After moxibustion treatment, testosterone, estradiol and testosterone/estradiol in patients were significantly increased(P<0.01 or P<0.05), and the content of PSA was significantly decreased(P<0.01).Conclusion: Moxibustion therapy can significantly alleviate the clinical symptoms of benign prostatic hyperplasia patients and improve their quality of life. Its mechanism may be through improving the levels of testosterone,estradiol and testosterone, and at the same time reducing the level of PSA.
作者
陈勇
夏光荣
何伟
唐成林
罗翱
曹净
张毅
高睿琦
郭全虎
CHEN Yong;XIA Guang-rong;HE Wei;TANG Cheng-lin;LUO Ao;CAO Jing;ZHANG Yi;GAO Rui-qi;GUO Quan-hu(The People's Hospital of Chongqing,Chongqing 400014,China;Jiangjin Hospital of Chinese Medicine in Chongqing,Chongqing 402260,China;College of Traditional Chinese Medicine, Chongqing Medical University,Chongqing 400016,China)
出处
《中医药导报》
2019年第2期112-115,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
重庆市卫生和计生委中医药科技项目(ZY20150220)
关键词
良性前列腺增生
艾灸
睾酮
雌二醇
前列腺特异性抗原
benign prostatic hyperplasia
moxibustion
testosterone
estradiol
prostate specific antigen
