摘要
目的研究妥洛特罗贴剂(阿米迪)佐治婴幼儿毛细支气管炎的临床疗效和安全性分析。方法选取2017年11月—2018年2月在蚌埠医学院第一附属医院儿科就诊的毛细支气管炎的患儿共103例,按照就诊日期的单双日分为治疗组52例(单日就诊)和对照组51例(双日就诊)。2组患儿均给予雾化吸入布地奈德混悬液及热毒宁注射液抗病毒治疗,若合并有细菌感染者加用敏感抗菌药物,必要时给予吸氧、镇静、止咳、化痰等对症支持治疗。治疗组患儿在常规治疗的基础上加用妥洛特罗贴剂,而对照组患儿在常规治疗的基础上加用硫酸沙丁胺醇溶液雾化吸入;比较治疗前后2组患儿临床表现改善情况、住院时间,同时通过临床表现及相关实验室检查观察是否出现其他严重不良反应。结果治疗组的有效率明显高于对照组,差异有统计学意义(P <0. 05);治疗组患儿的咳嗽好转时间、喘憋缓解时间、肺部哮鸣音消失时间、患儿住院时间均显著短于对照组,差异有统计学意义(均P <0. 05);且治疗组患儿不良反应发生例数较对照组明显少,程度亦相对较轻,差异有统计学意义(P <0. 05)。结论妥洛特罗贴剂佐治婴幼儿毛细支气管炎疗效显著,安全性较高,使用方便且不良反应相对较少,值得在临床上推广。
Objective To study the clinical efficacy and safety of Tulobuterol patch( Amiaid) in the treatment of bronchiolitis in infants. Methods The 103 infants with bronchiolitis in Department of Pediatrics of the First Affiliated Hospital of Bengbu Medical College from November 2017 to February 2018 were enrolled into this study,and divided into treatment group( n = 52) and control group( n = 51) according to the date of the doctor’s day. The patients in both groups received atomized inhalation of Budesonide suspension and Reduning injection,and sensitive antibiotics were administrated if combined with bacterial infections. When necessary,oxygen therapy,sedation,controlling cough,dilution phlegm and other symptomatic support treatment were performed. The children in the treatment group received additional tulobuterol patch,while the children in the control group received additional atomized inhalation of Albuterol sulfate inhalation solution. The improvement of clinical performance,hospitalization time and the incidence of severe adverse reactions were compared between the two groups before and after the treatment. Results The effective rate in the treatment group was significantly higher than that in the control group( P < 0. 05),and the difference was statistically significant. The time for improvement of the cough,the duration of asthma,the loss of asthma in the lungs,and the length of hospital stay in the treatment group were significantly shorter those in the control group,the difference was statistically significant( all P < 0. 05). The incidence and severity of adverse reactions in the treatment group was lower than those in the control group,and the difference was statistically significant( P < 0. 05). Conclusion The effect of Tulobuterol patch on the bronchiolitis of infants is significant,with highly secure,convenient and few adverse reaction,and it is worth spreading in clinical practice.
作者
王文辉
张阵
彭万胜
赵武
WANG Wen-hui;ZHANG Zhen;PENG Wan-sheng(Graduate Department of Bengbu Medical College,Bengbu,Anhui 233000,China)
出处
《中华全科医学》
2019年第1期29-31,共3页
Chinese Journal of General Practice
基金
安徽省自然科学基金项目(1608085QH188)
