摘要
目的探究分析胶质瘤患者术后伴随癫痫的临床特征及组织中高迁移率族蛋白B1(high mobility group box protein B1,HMGB1)的表达情况。方法选择温州市人民医院2013年1月—2017年6月收治的101例胶质瘤术后痫性再发的患者,并选择同期该院收治的胶质瘤未发癫痫的患者70例、无肿瘤仅发癫痫的患者70例以及进行颅内减压手术的患者50例。比较胶质瘤并癫痫患者的临床病理因素对HMGB1表达的影响,比较4组患者的HMGB1表达情况,分析胶质瘤病理级别、癫痫的存在与否与胶质瘤组织中HMGB1表达的影响。结果胶质瘤并癫痫组患者致痫灶组织中HMGB1的表达与患者的性别、年龄和致痫灶所处位置差异无统计学意义(均P>0. 05);患者致痫灶组织中HMGB1的表达与患者的胶质瘤病理级别、癫痫持续时间和发作频率有明显相关性,差异具有统计学意义(均P <0. 05)。胶质瘤并癫痫组的HMGB1阳性表达量高于胶质瘤非癫痫组、无肿瘤癫痫组的HMGB1阳性表达量。对胶质瘤并癫痫组和胶质瘤非癫痫组不同病理级别的HMGB1的表达,低病理级别组中,胶质瘤并癫痫组患者的HMGB1表达量更高,差异有统计学意义(P <0. 05);高病理级别组中,胶质瘤并癫痫组患者的HMGB1表达量与胶质瘤非癫痫组相比,差异无统计学意义(P> 0. 05)。结论胶质瘤术后伴随痫性患者的胶质瘤组织中HMGB1表达量高,并与患者的病理级别、癫痫持续时间和发作频率有关,HMGB1的高表达可能与癫痫发作有关,具有临床研究价值。
Objective To investigate and analyze the clinical features of postoperative seizures of glioma patients and the expression of high mobility group box B1 protein in glioma tissues. Methods One hundred and one cases of glioma with recurrent epileptic seizure,70 cases of glioma without seizure,70 cases of epileptic seizure without glioma and 50 cases of cranial decompression in our hospital between January 2013 and June 2017 were enrolled into this study. The clinical pathological factors that affected the expression of HMGB in the glioma patients with epileptic seizure were explored. The expression of HMGB1 in the brain tissues were compared among the four groups. The effects of pathological grade of glioma and the accompanied with epilepsy on the expression of HMGB1 were analyzed. Results The expression of HMGB1 in epileptogenic focus tissues was not obviously related to the gender,age and location of the epileptogenic foci in the Glioma patients with epileptic seizure( all P > 0. 05),however,it significantly related to the pathological grade of glioma,episode time and frequency( all P < 0. 05). The positive expression of HMGB1 in the glioma group with epilepsy was higher than that in other three groups. In the patients with lower pathological grade glioma,the expression of HMGB1 in glioma patients with epileptic seizure was higher than that in the glioma patients without seizure,the difference was significant( P < 0. 05). In the patients with higher pathological grade glioma,there was no significant difference in the expression of HMGB1 between glioma patients with epileptic seizure and without seizure( P > 0. 05). Conclusion The expression of HMGB1 in glioma patients with recurrent epileptic seizure is high,which is associated with the histological grade,episode time and seizure frequency. The high expression of HMGB1 may be related to epilepsy,its clinical research value should be paid.
作者
吴昊
金鹏程
郑卜毅
童凌云
张晨晖
朱鹏磊
WU Hao;JIN Peng-cheng;ZHENG Bu-yi(Department of Neurosurgery,Wenzhou People's Hospital,Wenzhou,Zhejiang 325000,China)
出处
《中华全科医学》
2019年第1期52-54,58,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2014KYB257)
