摘要
细胞周期(cell cycle)是一种非常复杂和精细的调节过程,该过程是连续而不可逆的。细胞周期紊乱与很多疾病的发生发展有关,如肿瘤等。目前的研究发现,表观遗传学(epigenetics)可以通过影响细胞周期关键性调控因素而调控细胞周期。DNA甲基化(DNA methylation)是最常见的表观遗传修饰方式,其在基因的转录、基因组的稳定性和细胞周期的调控中发挥重要的作用。因此,该文重点对近年来DNA甲基化在细胞周期调控中的研究进展作一综述,以期为提高肿瘤等疾病的临床诊断和治疗水平提供理论依据。
Cell cycle is a very complex and precise regulation process, which is continuous and irreversible. Cell cycle disorder is an important pathology for cancer and age-related diseases. Recently, epigenetics may be changed through cell division and proliferation and stable genetic phenomenon. DNA methylation is the most common epigenetic modification. DNA methylation plays a critical role in the regulation of gene transcription, genome stability, cell cycle and so on. The data found that epigenetic pattern abnormal caused the cell cycle disorder is an important mechanism for cancer and age-related diseases. DNA methylation can affect cell cycle by regulating the key factors of cell cycle regulation. In this paper, the effects of DNA methylation on the cell cycle are reviewed, in order to provide a theoretical basis for improving the clinical diagnosis and treatment of tumors and other diseases in the future.
作者
董锁花
王芳
包金风
Dong Suohua;Wang Fang;Bao Jinfeng(Basic Medical School,lnner Mongolia Medical University,Huhhot 010110,China;Department of Pharmacy,the People's Hospital of Shanting District,Zaozhuang 277200,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2018年第12期2083-2089,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81541160)
内蒙古自然科学基金(批准号:2015MS0312)
内蒙古医科大学百万工程基金(批准号:YKD2014KJB002)资助的课题~~
